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Obesity: An independent protective factor for localized renal cell carcinoma in a systemic inflammation state
OBJECTIVES: To explore the prognostic value of obesity (measured by BMI) on RCC in a systemic inflammation state. PATIENTS AND METHODS: Clinicopathological and hematological data of 540 surgically treated Chinese localized RCC patients between 2005 and 2010 were retrospectively collected. Found by r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Urologia
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239303/ https://www.ncbi.nlm.nih.gov/pubmed/32213207 http://dx.doi.org/10.1590/S1677-5538.IBJU.2019.0228 |
Sumario: | OBJECTIVES: To explore the prognostic value of obesity (measured by BMI) on RCC in a systemic inflammation state. PATIENTS AND METHODS: Clinicopathological and hematological data of 540 surgically treated Chinese localized RCC patients between 2005 and 2010 were retrospectively collected. Found by receiver operating characteristic (ROC) curve for cancer-specific survival (CSS), the optimal cutoff values of neutrophil-lymphocyte ratio (NLR, an indicator of systemic inflammation state) and BMI were 2.12 and 23.32, respectively. Survival curves were drawn using Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of BMI in localized RCC patients with different NLR. RESULTS: Overall, 36 patients died with a median follow-up of 70 months. Median overall survival (OS) was 66 months and the 5-year OS rate was 92.7%. In the multivariate analysis of total patients, higher BMI was an independent protective factor for CSS in total patients (p=0.048). While in systemic inflammation subgroup (high NLR subgroup) patients, higher BMI (obesity) turned out to be an independent protective factor for both CSS (p=0.025) and RFS (p=0.048). CONCLUSION: In localized RCC patients, obesity was an independent protective factor for CSS and RFS in a systemic inflammation state. |
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