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Obesity: An independent protective factor for localized renal cell carcinoma in a systemic inflammation state
OBJECTIVES: To explore the prognostic value of obesity (measured by BMI) on RCC in a systemic inflammation state. PATIENTS AND METHODS: Clinicopathological and hematological data of 540 surgically treated Chinese localized RCC patients between 2005 and 2010 were retrospectively collected. Found by r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Urologia
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239303/ https://www.ncbi.nlm.nih.gov/pubmed/32213207 http://dx.doi.org/10.1590/S1677-5538.IBJU.2019.0228 |
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author | Liu, Zhenhua Wang, Haifeng Chen, Yuke Jin, Jie Yu, Wei |
author_facet | Liu, Zhenhua Wang, Haifeng Chen, Yuke Jin, Jie Yu, Wei |
author_sort | Liu, Zhenhua |
collection | PubMed |
description | OBJECTIVES: To explore the prognostic value of obesity (measured by BMI) on RCC in a systemic inflammation state. PATIENTS AND METHODS: Clinicopathological and hematological data of 540 surgically treated Chinese localized RCC patients between 2005 and 2010 were retrospectively collected. Found by receiver operating characteristic (ROC) curve for cancer-specific survival (CSS), the optimal cutoff values of neutrophil-lymphocyte ratio (NLR, an indicator of systemic inflammation state) and BMI were 2.12 and 23.32, respectively. Survival curves were drawn using Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of BMI in localized RCC patients with different NLR. RESULTS: Overall, 36 patients died with a median follow-up of 70 months. Median overall survival (OS) was 66 months and the 5-year OS rate was 92.7%. In the multivariate analysis of total patients, higher BMI was an independent protective factor for CSS in total patients (p=0.048). While in systemic inflammation subgroup (high NLR subgroup) patients, higher BMI (obesity) turned out to be an independent protective factor for both CSS (p=0.025) and RFS (p=0.048). CONCLUSION: In localized RCC patients, obesity was an independent protective factor for CSS and RFS in a systemic inflammation state. |
format | Online Article Text |
id | pubmed-7239303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sociedade Brasileira de Urologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-72393032020-10-30 Obesity: An independent protective factor for localized renal cell carcinoma in a systemic inflammation state Liu, Zhenhua Wang, Haifeng Chen, Yuke Jin, Jie Yu, Wei Int Braz J Urol Original Article OBJECTIVES: To explore the prognostic value of obesity (measured by BMI) on RCC in a systemic inflammation state. PATIENTS AND METHODS: Clinicopathological and hematological data of 540 surgically treated Chinese localized RCC patients between 2005 and 2010 were retrospectively collected. Found by receiver operating characteristic (ROC) curve for cancer-specific survival (CSS), the optimal cutoff values of neutrophil-lymphocyte ratio (NLR, an indicator of systemic inflammation state) and BMI were 2.12 and 23.32, respectively. Survival curves were drawn using Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of BMI in localized RCC patients with different NLR. RESULTS: Overall, 36 patients died with a median follow-up of 70 months. Median overall survival (OS) was 66 months and the 5-year OS rate was 92.7%. In the multivariate analysis of total patients, higher BMI was an independent protective factor for CSS in total patients (p=0.048). While in systemic inflammation subgroup (high NLR subgroup) patients, higher BMI (obesity) turned out to be an independent protective factor for both CSS (p=0.025) and RFS (p=0.048). CONCLUSION: In localized RCC patients, obesity was an independent protective factor for CSS and RFS in a systemic inflammation state. Sociedade Brasileira de Urologia 2020-10-30 /pmc/articles/PMC7239303/ /pubmed/32213207 http://dx.doi.org/10.1590/S1677-5538.IBJU.2019.0228 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Liu, Zhenhua Wang, Haifeng Chen, Yuke Jin, Jie Yu, Wei Obesity: An independent protective factor for localized renal cell carcinoma in a systemic inflammation state |
title | Obesity: An independent protective factor for localized renal cell carcinoma in a systemic inflammation state |
title_full | Obesity: An independent protective factor for localized renal cell carcinoma in a systemic inflammation state |
title_fullStr | Obesity: An independent protective factor for localized renal cell carcinoma in a systemic inflammation state |
title_full_unstemmed | Obesity: An independent protective factor for localized renal cell carcinoma in a systemic inflammation state |
title_short | Obesity: An independent protective factor for localized renal cell carcinoma in a systemic inflammation state |
title_sort | obesity: an independent protective factor for localized renal cell carcinoma in a systemic inflammation state |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239303/ https://www.ncbi.nlm.nih.gov/pubmed/32213207 http://dx.doi.org/10.1590/S1677-5538.IBJU.2019.0228 |
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