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Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions

As COVID-19 is rapidly spreading across the globe, short-term modeling forecasts provide time-critical information for decisions on containment and mitigation strategies. A major challenge for short-term forecasts is the assessment of key epidemiological parameters and how they change when first int...

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Autores principales: Dehning, Jonas, Zierenberg, Johannes, Spitzner, F. Paul, Wibral, Michael, Neto, Joao Pinheiro, Wilczek, Michael, Priesemann, Viola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239331/
https://www.ncbi.nlm.nih.gov/pubmed/32414780
http://dx.doi.org/10.1126/science.abb9789
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author Dehning, Jonas
Zierenberg, Johannes
Spitzner, F. Paul
Wibral, Michael
Neto, Joao Pinheiro
Wilczek, Michael
Priesemann, Viola
author_facet Dehning, Jonas
Zierenberg, Johannes
Spitzner, F. Paul
Wibral, Michael
Neto, Joao Pinheiro
Wilczek, Michael
Priesemann, Viola
author_sort Dehning, Jonas
collection PubMed
description As COVID-19 is rapidly spreading across the globe, short-term modeling forecasts provide time-critical information for decisions on containment and mitigation strategies. A major challenge for short-term forecasts is the assessment of key epidemiological parameters and how they change when first interventions show an effect. By combining an established epidemiological model with Bayesian inference, we analyze the time dependence of the effective growth rate of new infections. Focusing on COVID-19 spread in Germany, we detect change points in the effective growth rate that correlate well with the times of publicly announced interventions. Thereby, we can quantify the effect of interventions, and we can incorporate the corresponding change points into forecasts of future scenarios and case numbers. Our code is freely available and can be readily adapted to any country or region.
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spelling pubmed-72393312020-05-21 Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions Dehning, Jonas Zierenberg, Johannes Spitzner, F. Paul Wibral, Michael Neto, Joao Pinheiro Wilczek, Michael Priesemann, Viola Science Research Articles As COVID-19 is rapidly spreading across the globe, short-term modeling forecasts provide time-critical information for decisions on containment and mitigation strategies. A major challenge for short-term forecasts is the assessment of key epidemiological parameters and how they change when first interventions show an effect. By combining an established epidemiological model with Bayesian inference, we analyze the time dependence of the effective growth rate of new infections. Focusing on COVID-19 spread in Germany, we detect change points in the effective growth rate that correlate well with the times of publicly announced interventions. Thereby, we can quantify the effect of interventions, and we can incorporate the corresponding change points into forecasts of future scenarios and case numbers. Our code is freely available and can be readily adapted to any country or region. American Association for the Advancement of Science 2020-05-15 /pmc/articles/PMC7239331/ /pubmed/32414780 http://dx.doi.org/10.1126/science.abb9789 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). http://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Dehning, Jonas
Zierenberg, Johannes
Spitzner, F. Paul
Wibral, Michael
Neto, Joao Pinheiro
Wilczek, Michael
Priesemann, Viola
Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions
title Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions
title_full Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions
title_fullStr Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions
title_full_unstemmed Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions
title_short Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions
title_sort inferring change points in the spread of covid-19 reveals the effectiveness of interventions
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239331/
https://www.ncbi.nlm.nih.gov/pubmed/32414780
http://dx.doi.org/10.1126/science.abb9789
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