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Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis
The innate immune system fights infection with inflammasomes and interferons. Facultative bacterial pathogens that inhabit the host cytosol avoid inflammasomes(1–6) and are often insensitive to type I interferons (IFN-I), but are restricted by IFN-γ(7–11). However, it remains unclear how obligate cy...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239376/ https://www.ncbi.nlm.nih.gov/pubmed/32123346 http://dx.doi.org/10.1038/s41564-020-0673-5 |