Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway

Glutathione (GSH), the most abundant nonprotein thiol functioning as an antioxidant, plays critical roles in maintaining the core functions of mesenchymal stem cells (MSCs), which are used as a cellular immunotherapy for graft-versus-host disease (GVHD). However, the role of GSH dynamics in MSCs rem...

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Detalles Bibliográficos
Autores principales: Lim, Jisun, Heo, Jinbeom, Ju, Hyein, Shin, Ji-Woong, Kim, YongHwan, Lee, Seungun, Yu, Hwan Yeul, Ryu, Chae-Min, Yun, HongDuck, Song, Sujin, Hong, Ki-Sung, Chung, Hyung-Min, Kim, Hwa-Ryeon, Roe, Jae-Seok, Choi, Kihang, Kim, In-Gyu, Jeong, Eui Man, Shin, Dong-Myung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239701/
https://www.ncbi.nlm.nih.gov/pubmed/32490200
http://dx.doi.org/10.1126/sciadv.aba1334

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