IRE1α and IGF signaling predict resistance to an endoplasmic reticulum stress-inducing drug in glioblastoma cells

To date current therapies of glioblastoma multiforme (GBM) are largely ineffective. The induction of apoptosis by an unresolvable unfolded protein response (UPR) represents a potential new therapeutic strategy. Here we tested 12ADT, a sarcoendoplasmic reticulum Ca(2+) ATPase (SERCA) inhibitor, on a...

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Detalles Bibliográficos
Autores principales: Rodvold, Jeffrey J., Xian, Su, Nussbacher, Julia, Tsui, Brian, Cameron Waller, T., Searles, Stephen C., Lew, Alyssa, Jiang, Pengfei, Babic, Ivan, Nomura, Natsuko, Lin, Jonathan H., Kesari, Santosh, Carter, Hannah, Zanetti, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239929/
https://www.ncbi.nlm.nih.gov/pubmed/32433555
http://dx.doi.org/10.1038/s41598-020-65320-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239929/
https://www.ncbi.nlm.nih.gov/pubmed/32433555
http://dx.doi.org/10.1038/s41598-020-65320-6

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