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Incidence, Prognostic Factors and Survival Outcome in Patients With Primary Hepatic Lymphoma

Aim: The objective of our study was to investigate the epidemiologic characteristics, prognostic factors and survival in patients with primary hepatic lymphoma (PHL). Methods: PHL patients diagnosed between 1983 and 2015 were identified from the SEER database. The temporal trend in PHL incidence was...

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Autores principales: Zhang, Shi-Long, Chen, Chen, Rao, Qian-Wen, Guo, Zhe, Wang, Xin, Wang, Zhi-Ming, Wang, Li-Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239999/
https://www.ncbi.nlm.nih.gov/pubmed/32477954
http://dx.doi.org/10.3389/fonc.2020.00750
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author Zhang, Shi-Long
Chen, Chen
Rao, Qian-Wen
Guo, Zhe
Wang, Xin
Wang, Zhi-Ming
Wang, Li-Shun
author_facet Zhang, Shi-Long
Chen, Chen
Rao, Qian-Wen
Guo, Zhe
Wang, Xin
Wang, Zhi-Ming
Wang, Li-Shun
author_sort Zhang, Shi-Long
collection PubMed
description Aim: The objective of our study was to investigate the epidemiologic characteristics, prognostic factors and survival in patients with primary hepatic lymphoma (PHL). Methods: PHL patients diagnosed between 1983 and 2015 were identified from the SEER database. The temporal trend in PHL incidence was assessed using joinpoint regression software. Overall survival(OS) and disease-specific survival (DSS) was evaluated using the Kaplan-Meier method and log-rank test. Univariate and multivariate Cox regression analysis was performed to identify the independent prognostic factors for OS and DSS. Nomograms to predict survival possibilities were constructed based on the identified independent prognostic factors. Results: A total of 1,182 patients were identified with PHL. The mean age was 61.7 ± 17.1 years with a male to female of 1.6:1. Diffuse large B-cell lymphoma (59.8%) was the most common histological subtype. The incidence of PHL steadily increasing by an annual percentage change (APC) of 2.6% (95% CI 2.0–3.2, P < 0.05). The 1-, 5-, and 10-year OS rates were 50.85, 39.6, and 30.4%, respectively, and the corresponding DSS rates were 55.3, 47.9, and 43.3%, respectively. Multivariate Cox regression analysis revealed that age, sex, race, marital status, histological subtype, surgery, and chemotherapy were independent prognostic factors for survival. Nomograms specifically for DLBCL were constructed to predict 1-, 5-, and 10-year OS and DSS possibility, respectively. The concordance index (C-index) and calibration plots showed the established nomograms had robust and accurate performance. Conclusion: PHL were rare but the incidence has been steadily increasing over the past four decades. Survival has improved in recent years. Surgery or chemotherapy could provide better OS and DSS. The established nomograms specifically for DLBCL were robust and accurate in predicting 1-, 5-, and 10-year OS and DSS.
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spelling pubmed-72399992020-05-29 Incidence, Prognostic Factors and Survival Outcome in Patients With Primary Hepatic Lymphoma Zhang, Shi-Long Chen, Chen Rao, Qian-Wen Guo, Zhe Wang, Xin Wang, Zhi-Ming Wang, Li-Shun Front Oncol Oncology Aim: The objective of our study was to investigate the epidemiologic characteristics, prognostic factors and survival in patients with primary hepatic lymphoma (PHL). Methods: PHL patients diagnosed between 1983 and 2015 were identified from the SEER database. The temporal trend in PHL incidence was assessed using joinpoint regression software. Overall survival(OS) and disease-specific survival (DSS) was evaluated using the Kaplan-Meier method and log-rank test. Univariate and multivariate Cox regression analysis was performed to identify the independent prognostic factors for OS and DSS. Nomograms to predict survival possibilities were constructed based on the identified independent prognostic factors. Results: A total of 1,182 patients were identified with PHL. The mean age was 61.7 ± 17.1 years with a male to female of 1.6:1. Diffuse large B-cell lymphoma (59.8%) was the most common histological subtype. The incidence of PHL steadily increasing by an annual percentage change (APC) of 2.6% (95% CI 2.0–3.2, P < 0.05). The 1-, 5-, and 10-year OS rates were 50.85, 39.6, and 30.4%, respectively, and the corresponding DSS rates were 55.3, 47.9, and 43.3%, respectively. Multivariate Cox regression analysis revealed that age, sex, race, marital status, histological subtype, surgery, and chemotherapy were independent prognostic factors for survival. Nomograms specifically for DLBCL were constructed to predict 1-, 5-, and 10-year OS and DSS possibility, respectively. The concordance index (C-index) and calibration plots showed the established nomograms had robust and accurate performance. Conclusion: PHL were rare but the incidence has been steadily increasing over the past four decades. Survival has improved in recent years. Surgery or chemotherapy could provide better OS and DSS. The established nomograms specifically for DLBCL were robust and accurate in predicting 1-, 5-, and 10-year OS and DSS. Frontiers Media S.A. 2020-05-14 /pmc/articles/PMC7239999/ /pubmed/32477954 http://dx.doi.org/10.3389/fonc.2020.00750 Text en Copyright © 2020 Zhang, Chen, Rao, Guo, Wang, Wang and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Shi-Long
Chen, Chen
Rao, Qian-Wen
Guo, Zhe
Wang, Xin
Wang, Zhi-Ming
Wang, Li-Shun
Incidence, Prognostic Factors and Survival Outcome in Patients With Primary Hepatic Lymphoma
title Incidence, Prognostic Factors and Survival Outcome in Patients With Primary Hepatic Lymphoma
title_full Incidence, Prognostic Factors and Survival Outcome in Patients With Primary Hepatic Lymphoma
title_fullStr Incidence, Prognostic Factors and Survival Outcome in Patients With Primary Hepatic Lymphoma
title_full_unstemmed Incidence, Prognostic Factors and Survival Outcome in Patients With Primary Hepatic Lymphoma
title_short Incidence, Prognostic Factors and Survival Outcome in Patients With Primary Hepatic Lymphoma
title_sort incidence, prognostic factors and survival outcome in patients with primary hepatic lymphoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239999/
https://www.ncbi.nlm.nih.gov/pubmed/32477954
http://dx.doi.org/10.3389/fonc.2020.00750
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