Rapidly Switchable Universal CAR-T Cells for Treatment of CD123-Positive Leukemia

Chimeric antigen receptor T cells (CAR-T) targeting CD19 or B cell maturation antigen (BCMA) are highly effective against B cell malignancies. However, application of CAR-T to less differentially expressed targets remains a challenge due to lack of tumor-specific antigens and CAR-T controllability....

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Detalles Bibliográficos
Autores principales: Loff, Simon, Dietrich, Josephine, Meyer, Jan-Erik, Riewaldt, Julia, Spehr, Johannes, von Bonin, Malte, Gründer, Cordula, Swayampakula, Mridula, Franke, Kristin, Feldmann, Anja, Bachmann, Michael, Ehninger, Gerhard, Ehninger, Armin, Cartellieri, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240059/
https://www.ncbi.nlm.nih.gov/pubmed/32462078
http://dx.doi.org/10.1016/j.omto.2020.04.009

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