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Diagnostic and Therapeutic Potential of microRNAs in Acute Kidney Injury

During hospital stay, about 20% of adult patients experience an episode of acute kidney injury (AKI), which is characterized by a rapid decrease in kidney function. Diagnostic tools regarding early diagnosis of kidney dysfunction prior to AKI and markers of renal recovery are not available. Addition...

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Autores principales: Brandenburger, Timo, Lorenzen, Johan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240101/
https://www.ncbi.nlm.nih.gov/pubmed/32477132
http://dx.doi.org/10.3389/fphar.2020.00657
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author Brandenburger, Timo
Lorenzen, Johan M.
author_facet Brandenburger, Timo
Lorenzen, Johan M.
author_sort Brandenburger, Timo
collection PubMed
description During hospital stay, about 20% of adult patients experience an episode of acute kidney injury (AKI), which is characterized by a rapid decrease in kidney function. Diagnostic tools regarding early diagnosis of kidney dysfunction prior to AKI and markers of renal recovery are not available. Additionally, there is no therapeutic option for the treatment of AKI. Thus, better and more specific diagnostic and therapeutic options are urgently needed in daily clinical practice. NoncodingRNAs (ncRNAs) have come into focus of research in the context of AKI in the last decade. The best characterized group of ncRNAs are microRNAs (miRNAs). An increasing body of literature has shown that miRNAs are involved in the pathogenesis of AKI and that they are promising future tools in the diagnosis and therapy of AKI. However, there are obstacles to be overcome before miRNAs can be transferred to patient care. This review will give an overview of our current knowledge of miRNA involvement in the context of AKI while critically evaluating their diagnostic and therapeutic potential.
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spelling pubmed-72401012020-05-29 Diagnostic and Therapeutic Potential of microRNAs in Acute Kidney Injury Brandenburger, Timo Lorenzen, Johan M. Front Pharmacol Pharmacology During hospital stay, about 20% of adult patients experience an episode of acute kidney injury (AKI), which is characterized by a rapid decrease in kidney function. Diagnostic tools regarding early diagnosis of kidney dysfunction prior to AKI and markers of renal recovery are not available. Additionally, there is no therapeutic option for the treatment of AKI. Thus, better and more specific diagnostic and therapeutic options are urgently needed in daily clinical practice. NoncodingRNAs (ncRNAs) have come into focus of research in the context of AKI in the last decade. The best characterized group of ncRNAs are microRNAs (miRNAs). An increasing body of literature has shown that miRNAs are involved in the pathogenesis of AKI and that they are promising future tools in the diagnosis and therapy of AKI. However, there are obstacles to be overcome before miRNAs can be transferred to patient care. This review will give an overview of our current knowledge of miRNA involvement in the context of AKI while critically evaluating their diagnostic and therapeutic potential. Frontiers Media S.A. 2020-05-14 /pmc/articles/PMC7240101/ /pubmed/32477132 http://dx.doi.org/10.3389/fphar.2020.00657 Text en Copyright © 2020 Brandenburger and Lorenzen http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Brandenburger, Timo
Lorenzen, Johan M.
Diagnostic and Therapeutic Potential of microRNAs in Acute Kidney Injury
title Diagnostic and Therapeutic Potential of microRNAs in Acute Kidney Injury
title_full Diagnostic and Therapeutic Potential of microRNAs in Acute Kidney Injury
title_fullStr Diagnostic and Therapeutic Potential of microRNAs in Acute Kidney Injury
title_full_unstemmed Diagnostic and Therapeutic Potential of microRNAs in Acute Kidney Injury
title_short Diagnostic and Therapeutic Potential of microRNAs in Acute Kidney Injury
title_sort diagnostic and therapeutic potential of micrornas in acute kidney injury
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240101/
https://www.ncbi.nlm.nih.gov/pubmed/32477132
http://dx.doi.org/10.3389/fphar.2020.00657
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