Cargando…

An Essential Membrane Protein Modulates the Proteolysis of LpxC to Control Lipopolysaccharide Synthesis in Escherichia coli

Gram-negative bacteria are surrounded by a complex cell envelope that includes two membranes. The outer membrane prevents many drugs from entering these cells and is thus a major determinant of their intrinsic antibiotic resistance. This barrier function is imparted by the asymmetric architecture of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fivenson, Elayne M., Bernhardt, Thomas G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240159/ https://www.ncbi.nlm.nih.gov/pubmed/32430473 http://dx.doi.org/10.1128/mBio.00939-20

Ejemplares similares

Intricate Crosstalk Between Lipopolysaccharide, Phospholipid and Fatty Acid Metabolism in Escherichia coli Modulates Proteolysis of LpxC
por: Thomanek, Nikolas, et al.
Publicado: (2019)

Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis
por: Mostafavi, Mina, et al.
Publicado: (2018)

The nucleotide-binding site of Aquifex aeolicus LpxC
por: Buetow, Lori, et al.
Publicado: (2006)

A New Factor LapD Is Required for the Regulation of LpxC Amounts and Lipopolysaccharide Trafficking
por: Wieczorek, Alicja, et al.
Publicado: (2022)

Regulated Expression of lpxC Allows for Reduction of Endotoxicity in Bordetella pertussis
por: Pérez-Ortega, Jesús, et al.
Publicado: (2022)

Machine learning approaches to study the structure-activity relationships of LpxC inhibitors
por: Yu, Tianshi, et al.
Publicado: (2023)

Regulation of the First Committed Step in Lipopolysaccharide Biosynthesis Catalyzed by LpxC Requires the Essential Protein LapC (YejM) and HslVU Protease
por: Biernacka, Daria, et al.
Publicado: (2020)

Suppressors of lapC Mutation Identify New Regulators of LpxC, Which Mediates the First Committed Step in Lipopolysaccharide Biosynthesis
por: Maniyeri, Akshay, et al.
Publicado: (2023)

Inhibition of LpxC Protects Mice from Resistant Acinetobacter baumannii by Modulating Inflammation and Enhancing Phagocytosis
por: Lin, Lin, et al.
Publicado: (2012)

Chlamydia spp. development is differentially altered by treatment with the LpxC inhibitor LPC-011
por: Cram, Erik D., et al.
Publicado: (2017)

3D-QSAR, Molecular Docking and Molecular Dynamics Simulation of Pseudomonas aeruginosa LpxC Inhibitors
por: Zuo, Ke, et al.
Publicado: (2017)

Inhibition of LpxC Increases the Activity of Iron Chelators and Gallium Nitrate in Multidrug-Resistant Acinetobacter baumannii
por: Vinuesa, Víctor, et al.
Publicado: (2021)

Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC
por: Lemaître, Nadine, et al.
Publicado: (2017)

Application of LpxC enzyme inhibitor to inhibit some fast-growing bacteria in human gut bacterial culturomics
por: Hou, Fengyi, et al.
Publicado: (2019)

LpxC Inhibitors as New Antibacterial Agents and Tools for Studying Regulation of Lipid A Biosynthesis in Gram-Negative Pathogens
por: Tomaras, Andrew P., et al.
Publicado: (2014)

Molecular Basis of Essentiality of Early Critical Steps in the Lipopolysaccharide Biogenesis in Escherichia coli K-12: Requirement of MsbA, Cardiolipin, LpxL, LpxM and GcvB
por: Gorzelak, Patrycja, et al.
Publicado: (2021)

Application of mouse model for evaluation of recombinant LpxC and GmhA as novel antigenic vaccine candidates of Glaesserella parasuis serotype 13
por: JIA, Yong C., et al.
Publicado: (2021)

TP0586532, a non-hydroxamate LpxC inhibitor, reduces LPS release and IL-6 production both in vitro and in vivo
por: Fujita, Kiyoko, et al.
Publicado: (2022)

lpxC and yafS are the Most Suitable Internal Controls to Normalize Real Time RT-qPCR Expression in the Phytopathogenic Bacteria Dickeya dadantii
por: Hommais, Florence, et al.
Publicado: (2011)

TP0586532, a Novel Non-Hydroxamate LpxC Inhibitor: Potentiating Effect on In Vitro Activity of Meropenem against Carbapenem-Resistant Enterobacteriaceae
por: Yoshida, Ippei, et al.
Publicado: (2022)

Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
por: Bohl, Heather O., et al.
Publicado: (2018)

LpxT-Dependent Phosphorylation of Lipid A in Escherichia coli Increases Resistance to Deoxycholate and Enhances Gut Colonization
por: Tian, Xudong, et al.
Publicado: (2021)

Regulatory mechanisms of lipopolysaccharide synthesis in Escherichia coli
por: Shu, Sheng, et al.
Publicado: (2022)

Checkpoints That Regulate Balanced Biosynthesis of Lipopolysaccharide and Its Essentiality in Escherichia coli
por: Klein, Gracjana, et al.
Publicado: (2021)

A role for the Gram-negative outer membrane in bacterial shape determination
por: Fivenson, Elayne M., et al.
Publicado: (2023)

A role for the Gram-negative outer membrane in bacterial shape determination
por: Fivenson, Elayne M., et al.
Publicado: (2023)

Prediction of the Closed Conformation and Insights into the Mechanism of the Membrane Enzyme LpxR
por: Saunders, Graham M., et al.
Publicado: (2018)

Influence of Core Oligosaccharide of Lipopolysaccharide to Outer Membrane Behavior of Escherichia coli
por: Wang, Zhou, et al.
Publicado: (2015)

Regulation of the Escherichia coli HipBA Toxin-Antitoxin System by Proteolysis
por: Hansen, Sonja, et al.
Publicado: (2012)

Identification of lptA, lpxE, and lpxO, Three Genes Involved in the Remodeling of Brucella Cell Envelope
por: Conde-Álvarez, Raquel, et al.
Publicado: (2018)

Overexpression of lpxT Gene in Escherichia coli Inhibits Cell Division and Causes Envelope Defects without Changing the Overall Phosphorylation Level of Lipid A
por: Falchi, Federica A., et al.
Publicado: (2020)

Allosteric activation of cell wall synthesis during bacterial growth
por: Shlosman, Irina, et al.
Publicado: (2023)

The Role of Outer Membrane Proteins and Lipopolysaccharides for the Sensitivity of Escherichia coli to Antimicrobial Peptides
por: Ebbensgaard, Anna, et al.
Publicado: (2018)

Correction: Regulation of the Escherichia coli HipBA Toxin-Antitoxin System by Proteolysis
por: Hansen, Sonja, et al.
Publicado: (2012)

Trapped lipopolysaccharide and LptD intermediates reveal lipopolysaccharide translocation steps across the Escherichia coli outer membrane
por: Li, Xuejun, et al.
Publicado: (2015)

Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis
por: Cho, Jae, et al.
Publicado: (2016)

Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography
por: Kroeck, Kyle G., et al.
Publicado: (2019)

Proteolysis-Dependent Remodeling of the Tubulin Homolog FtsZ at the Division Septum in Escherichia coli
por: Viola, Marissa G., et al.
Publicado: (2017)

The Copper Efflux Regulator CueR Is Subject to ATP-Dependent Proteolysis in Escherichia coli
por: Bittner, Lisa-Marie, et al.
Publicado: (2017)

Rough-type and loss of the LPS due to lpx genes deletions are associated with colistin resistance in multidrug-resistant clinical Escherichia coli isolates not harbouring mcr genes
por: Moosavian, Mojtaba, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jso6mrp2vlpngvhc4io9hol9le