The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models

Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in almost all cases of amyotrophic lateral sclerosis (ALS), and 20% of familial ALS cases are due to mutations in superoxide dismutase 1 (SOD1). Redox regulation is critical to maintain cellular homeostasis, although how this rela...

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Detalles Bibliográficos
Autores principales: Parakh, Sonam, Shadfar, Sina, Perri, Emma R., Ragagnin, Audrey M.G., Piattoni, Claudia V., Fogolín, Mariela B., Yuan, Kristy C., Shahheydari, Hamideh, Don, Emily K., Thomas, Collen J., Hong, Yuning, Comini, Marcelo A., Laird, Angela S., Spencer, Damian M., Atkin, Julie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240177/
https://www.ncbi.nlm.nih.gov/pubmed/32446203
http://dx.doi.org/10.1016/j.isci.2020.101097

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