Conserved statin-mediated activation of the p38-MAPK pathway protects Caenorhabditis elegans from the cholesterol-independent effects of statins

OBJECTIVE: Statins are a group of medications that reduce cholesterol synthesis by inhibiting the activity of HMG-CoA reductase, a key enzyme in the mevalonate pathway. The clinical use of statins to lower excess cholesterol levels has revolutionized the cardiovascular field and increased the surviv...

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Detalles Bibliográficos
Autores principales: Goncalves, Irina Langier, Tal, Sharon, Barki-Harrington, Liza, Sapir, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240216/
https://www.ncbi.nlm.nih.gov/pubmed/32339771
http://dx.doi.org/10.1016/j.molmet.2020.101003

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