Cargando…
Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females
OBJECTIVES: The number and activity of circulating EPCs were enhanced in premenopausal women contrast to postmenopausal females and age-matched males. Here, we investigated whether this favorable effect exists in premenopausal women and age-matched men with cigarette smoking. METHODS: In a cross-sec...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240658/ https://www.ncbi.nlm.nih.gov/pubmed/32455001 http://dx.doi.org/10.1155/2020/9352518 |
_version_ | 1783536931373580288 |
---|---|
author | Shao, Yijia Luo, Liang Ren, Zi Guo, Jiayi Xiao, Xingxing Huang, Jiana Zeng, Haitao Zhan, Hong |
author_facet | Shao, Yijia Luo, Liang Ren, Zi Guo, Jiayi Xiao, Xingxing Huang, Jiana Zeng, Haitao Zhan, Hong |
author_sort | Shao, Yijia |
collection | PubMed |
description | OBJECTIVES: The number and activity of circulating EPCs were enhanced in premenopausal women contrast to postmenopausal females and age-matched males. Here, we investigated whether this favorable effect exists in premenopausal women and age-matched men with cigarette smoking. METHODS: In a cross-sectional study, the number and activity of circulating EPCs and nitric oxide production (NO) as well as flow-mediated vasodilation (FMD) in both premenopausal women and age-matched men with or without cigarette smoking were studied. RESULTS: Compared with age-matched men with or without smoking, the number and function of circulating EPCs as well as NO level in premenopausal women were obviously higher than that in the former and not affected by smoking. The number and function of circulating EPCs as well as NO level in male smokers were shown to be the most strongly inhibited. Furthermore, there was significant correlation between EPC number and activity, plasma NO level, and NO secretion by EPCs and FMD. CONCLUSIONS: Estradiol was deemed to play an important role in enhancing the number and activity of EPCs and NO production in premenopausal women even when affected by smoking, which may be the important mechanisms underlying vascular protection of estradiol in premenopausal women, but not in age-matched men. |
format | Online Article Text |
id | pubmed-7240658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-72406582020-05-23 Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females Shao, Yijia Luo, Liang Ren, Zi Guo, Jiayi Xiao, Xingxing Huang, Jiana Zeng, Haitao Zhan, Hong Cardiol Res Pract Research Article OBJECTIVES: The number and activity of circulating EPCs were enhanced in premenopausal women contrast to postmenopausal females and age-matched males. Here, we investigated whether this favorable effect exists in premenopausal women and age-matched men with cigarette smoking. METHODS: In a cross-sectional study, the number and activity of circulating EPCs and nitric oxide production (NO) as well as flow-mediated vasodilation (FMD) in both premenopausal women and age-matched men with or without cigarette smoking were studied. RESULTS: Compared with age-matched men with or without smoking, the number and function of circulating EPCs as well as NO level in premenopausal women were obviously higher than that in the former and not affected by smoking. The number and function of circulating EPCs as well as NO level in male smokers were shown to be the most strongly inhibited. Furthermore, there was significant correlation between EPC number and activity, plasma NO level, and NO secretion by EPCs and FMD. CONCLUSIONS: Estradiol was deemed to play an important role in enhancing the number and activity of EPCs and NO production in premenopausal women even when affected by smoking, which may be the important mechanisms underlying vascular protection of estradiol in premenopausal women, but not in age-matched men. Hindawi 2020-05-12 /pmc/articles/PMC7240658/ /pubmed/32455001 http://dx.doi.org/10.1155/2020/9352518 Text en Copyright © 2020 Yijia Shao et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shao, Yijia Luo, Liang Ren, Zi Guo, Jiayi Xiao, Xingxing Huang, Jiana Zeng, Haitao Zhan, Hong Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females |
title | Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females |
title_full | Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females |
title_fullStr | Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females |
title_full_unstemmed | Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females |
title_short | Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females |
title_sort | smoking-induced inhibition of number and activity of endothelial progenitor cells and nitric oxide in males were reversed by estradiol in premenopausal females |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240658/ https://www.ncbi.nlm.nih.gov/pubmed/32455001 http://dx.doi.org/10.1155/2020/9352518 |
work_keys_str_mv | AT shaoyijia smokinginducedinhibitionofnumberandactivityofendothelialprogenitorcellsandnitricoxideinmaleswerereversedbyestradiolinpremenopausalfemales AT luoliang smokinginducedinhibitionofnumberandactivityofendothelialprogenitorcellsandnitricoxideinmaleswerereversedbyestradiolinpremenopausalfemales AT renzi smokinginducedinhibitionofnumberandactivityofendothelialprogenitorcellsandnitricoxideinmaleswerereversedbyestradiolinpremenopausalfemales AT guojiayi smokinginducedinhibitionofnumberandactivityofendothelialprogenitorcellsandnitricoxideinmaleswerereversedbyestradiolinpremenopausalfemales AT xiaoxingxing smokinginducedinhibitionofnumberandactivityofendothelialprogenitorcellsandnitricoxideinmaleswerereversedbyestradiolinpremenopausalfemales AT huangjiana smokinginducedinhibitionofnumberandactivityofendothelialprogenitorcellsandnitricoxideinmaleswerereversedbyestradiolinpremenopausalfemales AT zenghaitao smokinginducedinhibitionofnumberandactivityofendothelialprogenitorcellsandnitricoxideinmaleswerereversedbyestradiolinpremenopausalfemales AT zhanhong smokinginducedinhibitionofnumberandactivityofendothelialprogenitorcellsandnitricoxideinmaleswerereversedbyestradiolinpremenopausalfemales |