Cargando…
3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil
Drug delivery constitutes the formulations, technologies, and systems for the transport of pharmaceutical compounds to specific areas in the body to exert safe therapeutic effects. The main criteria for selecting the correct medium for drug delivery are the quantity of the drug being carried and the...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240736/ https://www.ncbi.nlm.nih.gov/pubmed/32340327 http://dx.doi.org/10.3390/polym12040986 |
_version_ | 1783536949677522944 |
---|---|
author | Mohan, Denesh Khairullah, Nur Fatin How, Yan Ping Sajab, Mohd Shaiful Kaco, Hatika |
author_facet | Mohan, Denesh Khairullah, Nur Fatin How, Yan Ping Sajab, Mohd Shaiful Kaco, Hatika |
author_sort | Mohan, Denesh |
collection | PubMed |
description | Drug delivery constitutes the formulations, technologies, and systems for the transport of pharmaceutical compounds to specific areas in the body to exert safe therapeutic effects. The main criteria for selecting the correct medium for drug delivery are the quantity of the drug being carried and the amount of time required to release the drug. Hence, this research aimed to improve the aforementioned criteria by synthesizing a medium based on calcium carbonate-nanocellulose composite and evaluating its efficiency as a medium for drug delivery. Specifically, the efficiency was assessed in terms of the rates of uptake and release of 5-fluorouracil. Through the evaluation of the morphological and chemical properties of the synthesized composite, the established 3D printing profiles of nanocellulose and CaCO(3) took place following the layer-by-layer films. The 3D printed double laminated CaCO(3)-nanocellulose managed to release the 5-fluorouracil as an effective single composition and in a time-controlled manner. |
format | Online Article Text |
id | pubmed-7240736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72407362020-06-11 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil Mohan, Denesh Khairullah, Nur Fatin How, Yan Ping Sajab, Mohd Shaiful Kaco, Hatika Polymers (Basel) Article Drug delivery constitutes the formulations, technologies, and systems for the transport of pharmaceutical compounds to specific areas in the body to exert safe therapeutic effects. The main criteria for selecting the correct medium for drug delivery are the quantity of the drug being carried and the amount of time required to release the drug. Hence, this research aimed to improve the aforementioned criteria by synthesizing a medium based on calcium carbonate-nanocellulose composite and evaluating its efficiency as a medium for drug delivery. Specifically, the efficiency was assessed in terms of the rates of uptake and release of 5-fluorouracil. Through the evaluation of the morphological and chemical properties of the synthesized composite, the established 3D printing profiles of nanocellulose and CaCO(3) took place following the layer-by-layer films. The 3D printed double laminated CaCO(3)-nanocellulose managed to release the 5-fluorouracil as an effective single composition and in a time-controlled manner. MDPI 2020-04-23 /pmc/articles/PMC7240736/ /pubmed/32340327 http://dx.doi.org/10.3390/polym12040986 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mohan, Denesh Khairullah, Nur Fatin How, Yan Ping Sajab, Mohd Shaiful Kaco, Hatika 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil |
title | 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil |
title_full | 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil |
title_fullStr | 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil |
title_full_unstemmed | 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil |
title_short | 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil |
title_sort | 3d printed laminated caco(3)-nanocellulose films as controlled-release 5-fluorouracil |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240736/ https://www.ncbi.nlm.nih.gov/pubmed/32340327 http://dx.doi.org/10.3390/polym12040986 |
work_keys_str_mv | AT mohandenesh 3dprintedlaminatedcaco3nanocellulosefilmsascontrolledrelease5fluorouracil AT khairullahnurfatin 3dprintedlaminatedcaco3nanocellulosefilmsascontrolledrelease5fluorouracil AT howyanping 3dprintedlaminatedcaco3nanocellulosefilmsascontrolledrelease5fluorouracil AT sajabmohdshaiful 3dprintedlaminatedcaco3nanocellulosefilmsascontrolledrelease5fluorouracil AT kacohatika 3dprintedlaminatedcaco3nanocellulosefilmsascontrolledrelease5fluorouracil |