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3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil

Drug delivery constitutes the formulations, technologies, and systems for the transport of pharmaceutical compounds to specific areas in the body to exert safe therapeutic effects. The main criteria for selecting the correct medium for drug delivery are the quantity of the drug being carried and the...

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Detalles Bibliográficos
Autores principales: Mohan, Denesh, Khairullah, Nur Fatin, How, Yan Ping, Sajab, Mohd Shaiful, Kaco, Hatika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240736/
https://www.ncbi.nlm.nih.gov/pubmed/32340327
http://dx.doi.org/10.3390/polym12040986
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author Mohan, Denesh
Khairullah, Nur Fatin
How, Yan Ping
Sajab, Mohd Shaiful
Kaco, Hatika
author_facet Mohan, Denesh
Khairullah, Nur Fatin
How, Yan Ping
Sajab, Mohd Shaiful
Kaco, Hatika
author_sort Mohan, Denesh
collection PubMed
description Drug delivery constitutes the formulations, technologies, and systems for the transport of pharmaceutical compounds to specific areas in the body to exert safe therapeutic effects. The main criteria for selecting the correct medium for drug delivery are the quantity of the drug being carried and the amount of time required to release the drug. Hence, this research aimed to improve the aforementioned criteria by synthesizing a medium based on calcium carbonate-nanocellulose composite and evaluating its efficiency as a medium for drug delivery. Specifically, the efficiency was assessed in terms of the rates of uptake and release of 5-fluorouracil. Through the evaluation of the morphological and chemical properties of the synthesized composite, the established 3D printing profiles of nanocellulose and CaCO(3) took place following the layer-by-layer films. The 3D printed double laminated CaCO(3)-nanocellulose managed to release the 5-fluorouracil as an effective single composition and in a time-controlled manner.
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spelling pubmed-72407362020-06-11 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil Mohan, Denesh Khairullah, Nur Fatin How, Yan Ping Sajab, Mohd Shaiful Kaco, Hatika Polymers (Basel) Article Drug delivery constitutes the formulations, technologies, and systems for the transport of pharmaceutical compounds to specific areas in the body to exert safe therapeutic effects. The main criteria for selecting the correct medium for drug delivery are the quantity of the drug being carried and the amount of time required to release the drug. Hence, this research aimed to improve the aforementioned criteria by synthesizing a medium based on calcium carbonate-nanocellulose composite and evaluating its efficiency as a medium for drug delivery. Specifically, the efficiency was assessed in terms of the rates of uptake and release of 5-fluorouracil. Through the evaluation of the morphological and chemical properties of the synthesized composite, the established 3D printing profiles of nanocellulose and CaCO(3) took place following the layer-by-layer films. The 3D printed double laminated CaCO(3)-nanocellulose managed to release the 5-fluorouracil as an effective single composition and in a time-controlled manner. MDPI 2020-04-23 /pmc/articles/PMC7240736/ /pubmed/32340327 http://dx.doi.org/10.3390/polym12040986 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mohan, Denesh
Khairullah, Nur Fatin
How, Yan Ping
Sajab, Mohd Shaiful
Kaco, Hatika
3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil
title 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil
title_full 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil
title_fullStr 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil
title_full_unstemmed 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil
title_short 3D Printed Laminated CaCO(3)-Nanocellulose Films as Controlled-Release 5-Fluorouracil
title_sort 3d printed laminated caco(3)-nanocellulose films as controlled-release 5-fluorouracil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240736/
https://www.ncbi.nlm.nih.gov/pubmed/32340327
http://dx.doi.org/10.3390/polym12040986
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