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Human gene and disease associations for clinical‐genomics and precision medicine research

We are entering the era of personalized medicine in which an individual's genetic makeup will eventually determine how a doctor can tailor his or her therapy. Therefore, it is becoming critical to understand the genetic basis of common diseases, for example, which genes predispose and rare gene...

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Autores principales: Ahmed, Zeeshan, Zeeshan, Saman, Mendhe, Dinesh, Dong, XinQi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240856/
https://www.ncbi.nlm.nih.gov/pubmed/32508008
http://dx.doi.org/10.1002/ctm2.28
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author Ahmed, Zeeshan
Zeeshan, Saman
Mendhe, Dinesh
Dong, XinQi
author_facet Ahmed, Zeeshan
Zeeshan, Saman
Mendhe, Dinesh
Dong, XinQi
author_sort Ahmed, Zeeshan
collection PubMed
description We are entering the era of personalized medicine in which an individual's genetic makeup will eventually determine how a doctor can tailor his or her therapy. Therefore, it is becoming critical to understand the genetic basis of common diseases, for example, which genes predispose and rare genetic variants contribute to diseases, and so on. Our study focuses on helping researchers, medical practitioners, and pharmacists in having a broad view of genetic variants that may be implicated in the likelihood of developing certain diseases. Our focus here is to create a comprehensive database with mobile access to all available, authentic and actionable genes, SNPs, and classified diseases and drugs collected from different clinical and genomics databases worldwide, including Ensembl, GenCode, ClinVar, GeneCards, DISEASES, HGMD, OMIM, GTR, CNVD, Novoseek, Swiss‐Prot, LncRNADisease, Orphanet, GWAS Catalog, SwissVar, COSMIC, WHO, and FDA. We present a new cutting‐edge gene‐SNP‐disease‐drug mobile database with a smart phone application, integrating information about classified diseases and related genes, germline and somatic mutations, and drugs. Its database includes over 59 000 protein‐coding and noncoding genes; over 67 000 germline SNPs and over a million somatic mutations reported for over 19 000 protein‐coding genes located in over 1000 regions, published with over 3000 articles in over 415 journals available at the PUBMED; over 80 000 ICDs; over 123 000 NDCs; and over 100 000 classified gene‐SNP‐disease associations. We present an application that can provide new insights into the information about genetic basis of human complex diseases and contribute to assimilating genomic with phenotypic data for the availability of gene‐based designer drugs, precise targeting of molecular fingerprints for tumor, appropriate drug therapy, predicting individual susceptibility to disease, diagnosis, and treatment of rare illnesses are all a few of the many transformations expected in the decade to come.
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spelling pubmed-72408562020-06-01 Human gene and disease associations for clinical‐genomics and precision medicine research Ahmed, Zeeshan Zeeshan, Saman Mendhe, Dinesh Dong, XinQi Clin Transl Med Research Articles We are entering the era of personalized medicine in which an individual's genetic makeup will eventually determine how a doctor can tailor his or her therapy. Therefore, it is becoming critical to understand the genetic basis of common diseases, for example, which genes predispose and rare genetic variants contribute to diseases, and so on. Our study focuses on helping researchers, medical practitioners, and pharmacists in having a broad view of genetic variants that may be implicated in the likelihood of developing certain diseases. Our focus here is to create a comprehensive database with mobile access to all available, authentic and actionable genes, SNPs, and classified diseases and drugs collected from different clinical and genomics databases worldwide, including Ensembl, GenCode, ClinVar, GeneCards, DISEASES, HGMD, OMIM, GTR, CNVD, Novoseek, Swiss‐Prot, LncRNADisease, Orphanet, GWAS Catalog, SwissVar, COSMIC, WHO, and FDA. We present a new cutting‐edge gene‐SNP‐disease‐drug mobile database with a smart phone application, integrating information about classified diseases and related genes, germline and somatic mutations, and drugs. Its database includes over 59 000 protein‐coding and noncoding genes; over 67 000 germline SNPs and over a million somatic mutations reported for over 19 000 protein‐coding genes located in over 1000 regions, published with over 3000 articles in over 415 journals available at the PUBMED; over 80 000 ICDs; over 123 000 NDCs; and over 100 000 classified gene‐SNP‐disease associations. We present an application that can provide new insights into the information about genetic basis of human complex diseases and contribute to assimilating genomic with phenotypic data for the availability of gene‐based designer drugs, precise targeting of molecular fingerprints for tumor, appropriate drug therapy, predicting individual susceptibility to disease, diagnosis, and treatment of rare illnesses are all a few of the many transformations expected in the decade to come. John Wiley and Sons Inc. 2020-05-03 /pmc/articles/PMC7240856/ /pubmed/32508008 http://dx.doi.org/10.1002/ctm2.28 Text en © 2020 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Ahmed, Zeeshan
Zeeshan, Saman
Mendhe, Dinesh
Dong, XinQi
Human gene and disease associations for clinical‐genomics and precision medicine research
title Human gene and disease associations for clinical‐genomics and precision medicine research
title_full Human gene and disease associations for clinical‐genomics and precision medicine research
title_fullStr Human gene and disease associations for clinical‐genomics and precision medicine research
title_full_unstemmed Human gene and disease associations for clinical‐genomics and precision medicine research
title_short Human gene and disease associations for clinical‐genomics and precision medicine research
title_sort human gene and disease associations for clinical‐genomics and precision medicine research
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240856/
https://www.ncbi.nlm.nih.gov/pubmed/32508008
http://dx.doi.org/10.1002/ctm2.28
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