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Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux

Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides, isoprenoids, amino acids, and numerous other bioproducts which are used in various industries. Metabolic engineering efforts aim to increase carbon flux towards acetyl-CoA in order to achieve higher productivities...

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Detalles Bibliográficos
Autores principales: Ku, Jason T., Chen, Arvin Y., Lan, Ethan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240943/
https://www.ncbi.nlm.nih.gov/pubmed/32340392
http://dx.doi.org/10.3390/metabo10040166
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author Ku, Jason T.
Chen, Arvin Y.
Lan, Ethan I.
author_facet Ku, Jason T.
Chen, Arvin Y.
Lan, Ethan I.
author_sort Ku, Jason T.
collection PubMed
description Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides, isoprenoids, amino acids, and numerous other bioproducts which are used in various industries. Metabolic engineering efforts aim to increase carbon flux towards acetyl-CoA in order to achieve higher productivities of its downstream products. In this review, we summarize the strategies that have been implemented for increasing acetyl-CoA flux and concentration, and discuss their effects. Furthermore, recent works have developed synthetic acetyl-CoA biosynthesis routes that achieve higher stoichiometric yield of acetyl-CoA from glycolytic substrates.
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spelling pubmed-72409432020-06-11 Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux Ku, Jason T. Chen, Arvin Y. Lan, Ethan I. Metabolites Review Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides, isoprenoids, amino acids, and numerous other bioproducts which are used in various industries. Metabolic engineering efforts aim to increase carbon flux towards acetyl-CoA in order to achieve higher productivities of its downstream products. In this review, we summarize the strategies that have been implemented for increasing acetyl-CoA flux and concentration, and discuss their effects. Furthermore, recent works have developed synthetic acetyl-CoA biosynthesis routes that achieve higher stoichiometric yield of acetyl-CoA from glycolytic substrates. MDPI 2020-04-23 /pmc/articles/PMC7240943/ /pubmed/32340392 http://dx.doi.org/10.3390/metabo10040166 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ku, Jason T.
Chen, Arvin Y.
Lan, Ethan I.
Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux
title Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux
title_full Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux
title_fullStr Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux
title_full_unstemmed Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux
title_short Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux
title_sort metabolic engineering design strategies for increasing acetyl-coa flux
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240943/
https://www.ncbi.nlm.nih.gov/pubmed/32340392
http://dx.doi.org/10.3390/metabo10040166
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