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The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation
The catabolism of intracellular triacylglycerols (TAGs) involves the activity of cytoplasmic and lysosomal enzymes. Cytoplasmic TAG hydrolysis, commonly termed lipolysis, is catalyzed by the sequential action of three major hydrolases, namely adipose triglyceride lipase, hormone-sensitive lipase, an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240967/ https://www.ncbi.nlm.nih.gov/pubmed/32290093 http://dx.doi.org/10.3390/metabo10040147 |
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author | Hofer, Peter Taschler, Ulrike Schreiber, Renate Kotzbeck, Petra Schoiswohl, Gabriele |
author_facet | Hofer, Peter Taschler, Ulrike Schreiber, Renate Kotzbeck, Petra Schoiswohl, Gabriele |
author_sort | Hofer, Peter |
collection | PubMed |
description | The catabolism of intracellular triacylglycerols (TAGs) involves the activity of cytoplasmic and lysosomal enzymes. Cytoplasmic TAG hydrolysis, commonly termed lipolysis, is catalyzed by the sequential action of three major hydrolases, namely adipose triglyceride lipase, hormone-sensitive lipase, and monoacylglycerol lipase. All three enzymes interact with numerous protein binding partners that modulate their activity, cellular localization, or stability. Deficiencies of these auxiliary proteins can lead to derangements in neutral lipid metabolism and energy homeostasis. In this review, we summarize the composition and the dynamics of the complex lipolytic machinery we like to call “lipolysome”. |
format | Online Article Text |
id | pubmed-7240967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72409672020-06-11 The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation Hofer, Peter Taschler, Ulrike Schreiber, Renate Kotzbeck, Petra Schoiswohl, Gabriele Metabolites Review The catabolism of intracellular triacylglycerols (TAGs) involves the activity of cytoplasmic and lysosomal enzymes. Cytoplasmic TAG hydrolysis, commonly termed lipolysis, is catalyzed by the sequential action of three major hydrolases, namely adipose triglyceride lipase, hormone-sensitive lipase, and monoacylglycerol lipase. All three enzymes interact with numerous protein binding partners that modulate their activity, cellular localization, or stability. Deficiencies of these auxiliary proteins can lead to derangements in neutral lipid metabolism and energy homeostasis. In this review, we summarize the composition and the dynamics of the complex lipolytic machinery we like to call “lipolysome”. MDPI 2020-04-10 /pmc/articles/PMC7240967/ /pubmed/32290093 http://dx.doi.org/10.3390/metabo10040147 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hofer, Peter Taschler, Ulrike Schreiber, Renate Kotzbeck, Petra Schoiswohl, Gabriele The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation |
title | The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation |
title_full | The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation |
title_fullStr | The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation |
title_full_unstemmed | The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation |
title_short | The Lipolysome—A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation |
title_sort | lipolysome—a highly complex and dynamic protein network orchestrating cytoplasmic triacylglycerol degradation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240967/ https://www.ncbi.nlm.nih.gov/pubmed/32290093 http://dx.doi.org/10.3390/metabo10040147 |
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