H‐reflex conditioning during locomotion in people with spinal cord injury

KEY POINTS: In people or animals with incomplete spinal cord injury (SCI), changing a spinal reflex through an operant conditioning protocol can improve locomotion. All previous studies conditioned the reflex during steady‐state maintenance of a specific posture. By contrast, the present study down‐conditioned the reflex during the swing‐phase of locomotion in people with hyperreflexia as a result of chronic incomplete SCI. The aim was to modify the functioning of the reflex in a specific phase of a dynamic movement. This novel swing‐phase conditioning protocol decreased the reflex much faster and farther than did the steady‐state protocol in people or animals with or without SCI, and it also improved locomotion. The reflex decrease persisted for at least 6 months after conditioning ended. The results suggest that conditioning reflex function in a specific phase of a dynamic movement offers a new approach to enhancing and/or accelerating recovery after SCI or in other disorders. ABSTRACT: In animals and people with incomplete spinal cord injury, appropriate operant conditioning of a spinal reflex can improve impaired locomotion. In all previous conditioning studies, the reflex was conditioned during steady‐state maintenance of a stable posture; this steady‐state protocol aimed to change the excitability of the targeted reflex pathway; reflex size gradually changed over 8–10 weeks. The present study introduces a new protocol, comprising a dynamic protocol that aims to change the functioning of the reflex pathway during a specific phase of a complex movement. Specifically, we down‐conditioned the soleus H‐reflex during the swing‐phase of locomotion in people with hyperreflexia as a result of chronic incomplete SCI. The swing‐phase H‐reflex, which is absent or very small in neurologically normal individuals, is abnormally large in this patient population. The results were clear. With swing‐phase down‐conditioning, the H‐reflex decreased much faster and farther than did the H‐reflex in all previous animal or human studies with the steady‐state protocol, and the decrease persisted for at least 6 months after conditioning ended. The H‐reflex decrease was accompanied by improvements in walking speed and in the modulation of locomotor electromyograph activity in proximal and distal muscles of both legs. These results provide new insight into the factors controlling spinal reflex conditioning; they suggest that the conditioning protocols targeting reflex function in a specific movement phase provide a promising new opportunity to enhance functional recovery after SCI or in other disorders.