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Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic in early 2020. The infection has been associated with a wide range of clinical symptoms. In the severely affected patients, it has caused dysregulation of immune responses including over-secretion of inflam...

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Autores principales: Noroozi, Rezvan, Branicki, Wojciech, Pyrc, Krzysztof, Łabaj, Paweł P., Pospiech, Ewelina, Taheri, Mohammad, Ghafouri-Fard, Soudeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241386/
https://www.ncbi.nlm.nih.gov/pubmed/32460144
http://dx.doi.org/10.1016/j.cyto.2020.155143
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author Noroozi, Rezvan
Branicki, Wojciech
Pyrc, Krzysztof
Łabaj, Paweł P.
Pospiech, Ewelina
Taheri, Mohammad
Ghafouri-Fard, Soudeh
author_facet Noroozi, Rezvan
Branicki, Wojciech
Pyrc, Krzysztof
Łabaj, Paweł P.
Pospiech, Ewelina
Taheri, Mohammad
Ghafouri-Fard, Soudeh
author_sort Noroozi, Rezvan
collection PubMed
description The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic in early 2020. The infection has been associated with a wide range of clinical symptoms. In the severely affected patients, it has caused dysregulation of immune responses including over-secretion of inflammatory cytokines and imbalances in the proportion of naïve helper T cells, memory helper T cells and regulatory T cells. Identification of the underlying mechanism of such aberrant function of immune system would help in the prediction of disease course and selection of susceptible patients for more intensive cares. In the current review, we summarize the results of studies which reported alterations in cytokine levels and immune cell functions in patients affected with SARS-CoV-2 and related viruses.
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spelling pubmed-72413862020-05-21 Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions Noroozi, Rezvan Branicki, Wojciech Pyrc, Krzysztof Łabaj, Paweł P. Pospiech, Ewelina Taheri, Mohammad Ghafouri-Fard, Soudeh Cytokine Article The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic in early 2020. The infection has been associated with a wide range of clinical symptoms. In the severely affected patients, it has caused dysregulation of immune responses including over-secretion of inflammatory cytokines and imbalances in the proportion of naïve helper T cells, memory helper T cells and regulatory T cells. Identification of the underlying mechanism of such aberrant function of immune system would help in the prediction of disease course and selection of susceptible patients for more intensive cares. In the current review, we summarize the results of studies which reported alterations in cytokine levels and immune cell functions in patients affected with SARS-CoV-2 and related viruses. Elsevier Ltd. 2020-09 2020-05-21 /pmc/articles/PMC7241386/ /pubmed/32460144 http://dx.doi.org/10.1016/j.cyto.2020.155143 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Noroozi, Rezvan
Branicki, Wojciech
Pyrc, Krzysztof
Łabaj, Paweł P.
Pospiech, Ewelina
Taheri, Mohammad
Ghafouri-Fard, Soudeh
Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions
title Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions
title_full Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions
title_fullStr Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions
title_full_unstemmed Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions
title_short Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions
title_sort altered cytokine levels and immune responses in patients with sars-cov-2 infection and related conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241386/
https://www.ncbi.nlm.nih.gov/pubmed/32460144
http://dx.doi.org/10.1016/j.cyto.2020.155143
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