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S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19

The novel corona virus (SARS-CoV-2) that causes severe acute respiratory syndrome, now called COVID-19 initially originated in Wuhan city of China and later spread across borders and infected more than five million people and killed over 3.4 lakh people all over the globe. This disease has been anno...

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Autores principales: Arafah, Azher, Ali, Shafat, Yatoo, Ali Mohd, Ali, Md. Niamat, Rehman, Muneeb U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IMSS. Published by Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241389/
https://www.ncbi.nlm.nih.gov/pubmed/32493626
http://dx.doi.org/10.1016/j.arcmed.2020.05.013
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author Arafah, Azher
Ali, Shafat
Yatoo, Ali Mohd
Ali, Md. Niamat
Rehman, Muneeb U.
author_facet Arafah, Azher
Ali, Shafat
Yatoo, Ali Mohd
Ali, Md. Niamat
Rehman, Muneeb U.
author_sort Arafah, Azher
collection PubMed
description The novel corona virus (SARS-CoV-2) that causes severe acute respiratory syndrome, now called COVID-19 initially originated in Wuhan city of China and later spread across borders and infected more than five million people and killed over 3.4 lakh people all over the globe. This disease has been announced as pandemic by WHO. So far, there has been not much progress in terms of drug development for fighting against this deadliest virus, also no existing drugs has been reported completely effective for COVID-19 treatment owing to lack of effective therapeutic targets and a broad understanding of the viral behavior in target cell. Some reports have found and confirmed that SARS-CoV-2 like others SARS-CoVs utilizes angiotensin converting enzyme-2 receptor for making entry into target cell by binding to the receptor with its S1 subunit and employing host cell proteases for cleaving S2 subunit at S2’ in order to fuse with cell membrane. Thus, simultaneous blocking of S1 subunit and inactivation of proteases seem to be promising therapeutic targets for the development of effective novel drugs. In current write up we hypothesize that S1 subunit and host proteases as potential therapeutic avenues for the treatment of COVID-19.
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spelling pubmed-72413892020-05-21 S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19 Arafah, Azher Ali, Shafat Yatoo, Ali Mohd Ali, Md. Niamat Rehman, Muneeb U. Arch Med Res Opinion The novel corona virus (SARS-CoV-2) that causes severe acute respiratory syndrome, now called COVID-19 initially originated in Wuhan city of China and later spread across borders and infected more than five million people and killed over 3.4 lakh people all over the globe. This disease has been announced as pandemic by WHO. So far, there has been not much progress in terms of drug development for fighting against this deadliest virus, also no existing drugs has been reported completely effective for COVID-19 treatment owing to lack of effective therapeutic targets and a broad understanding of the viral behavior in target cell. Some reports have found and confirmed that SARS-CoV-2 like others SARS-CoVs utilizes angiotensin converting enzyme-2 receptor for making entry into target cell by binding to the receptor with its S1 subunit and employing host cell proteases for cleaving S2 subunit at S2’ in order to fuse with cell membrane. Thus, simultaneous blocking of S1 subunit and inactivation of proteases seem to be promising therapeutic targets for the development of effective novel drugs. In current write up we hypothesize that S1 subunit and host proteases as potential therapeutic avenues for the treatment of COVID-19. IMSS. Published by Elsevier Inc. 2020-10 2020-05-21 /pmc/articles/PMC7241389/ /pubmed/32493626 http://dx.doi.org/10.1016/j.arcmed.2020.05.013 Text en © 2020 IMSS. Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Opinion
Arafah, Azher
Ali, Shafat
Yatoo, Ali Mohd
Ali, Md. Niamat
Rehman, Muneeb U.
S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19
title S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19
title_full S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19
title_fullStr S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19
title_full_unstemmed S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19
title_short S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19
title_sort s1 subunit and host proteases as potential therapeutic avenues for the treatment of covid-19
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241389/
https://www.ncbi.nlm.nih.gov/pubmed/32493626
http://dx.doi.org/10.1016/j.arcmed.2020.05.013
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