Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy

With the development of photodynamic therapy (PDT), remarkable studies have been conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of chemical modifications of the porphyrin skeleton have been introduced to improve cellular delivery, stability, and selectivity for can...

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Detalles Bibliográficos
Autores principales: Lin, Yuyan, Zhou, Tao, Bai, Renren, Xie, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241559/
https://www.ncbi.nlm.nih.gov/pubmed/32329382
http://dx.doi.org/10.1080/14756366.2020.1755669
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author Lin, Yuyan
Zhou, Tao
Bai, Renren
Xie, Yuanyuan
author_facet Lin, Yuyan
Zhou, Tao
Bai, Renren
Xie, Yuanyuan
author_sort Lin, Yuyan
collection PubMed
description With the development of photodynamic therapy (PDT), remarkable studies have been conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of chemical modifications of the porphyrin skeleton have been introduced to improve cellular delivery, stability, and selectivity for cancerous tissues. This review aims to highlight the developments in porphyrin-based structural modifications, with a specific emphasis on the role of PDT in anticancer treatment and the design of PSs to achieve a synergistic effect on multiple targets.
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spelling pubmed-72415592020-06-01 Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy Lin, Yuyan Zhou, Tao Bai, Renren Xie, Yuanyuan J Enzyme Inhib Med Chem Review Article With the development of photodynamic therapy (PDT), remarkable studies have been conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of chemical modifications of the porphyrin skeleton have been introduced to improve cellular delivery, stability, and selectivity for cancerous tissues. This review aims to highlight the developments in porphyrin-based structural modifications, with a specific emphasis on the role of PDT in anticancer treatment and the design of PSs to achieve a synergistic effect on multiple targets. Taylor & Francis 2020-04-24 /pmc/articles/PMC7241559/ /pubmed/32329382 http://dx.doi.org/10.1080/14756366.2020.1755669 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lin, Yuyan
Zhou, Tao
Bai, Renren
Xie, Yuanyuan
Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy
title Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy
title_full Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy
title_fullStr Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy
title_full_unstemmed Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy
title_short Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy
title_sort chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241559/
https://www.ncbi.nlm.nih.gov/pubmed/32329382
http://dx.doi.org/10.1080/14756366.2020.1755669
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