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Mid-upper arm circumference as a simple tool for identifying central obesity and insulin resistance in type 2 diabetes

BACKGROUND: Our research aimed to explore the correlation between mid-upper arm circumference (MUAC) and central obesity and insulin resistance (IR) in Chinese subjects with type 2 diabetes. MATERIALS: A total of 103 participants (60 men) were recruited in our study. MUAC was measured around the mid...

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Autores principales: Zhu, Yanhua, Lin, Qiongyan, Zhang, Yao, Deng, Hongrong, Hu, Xiling, Yang, Xubin, Yao, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241705/
https://www.ncbi.nlm.nih.gov/pubmed/32437358
http://dx.doi.org/10.1371/journal.pone.0231308
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author Zhu, Yanhua
Lin, Qiongyan
Zhang, Yao
Deng, Hongrong
Hu, Xiling
Yang, Xubin
Yao, Bin
author_facet Zhu, Yanhua
Lin, Qiongyan
Zhang, Yao
Deng, Hongrong
Hu, Xiling
Yang, Xubin
Yao, Bin
author_sort Zhu, Yanhua
collection PubMed
description BACKGROUND: Our research aimed to explore the correlation between mid-upper arm circumference (MUAC) and central obesity and insulin resistance (IR) in Chinese subjects with type 2 diabetes. MATERIALS: A total of 103 participants (60 men) were recruited in our study. MUAC was measured around the mid-arm between the shoulder and elbow. Waist circumference (WC) was obtained as central obesity parameter, and the IR parameter of Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) was calculated. The subjects were divided into three groups according to the tertiles cut-points of MUAC level. RESULTS: Body mass index (BMI), WC, the percentages of central obesity and HOMA-IR were significantly higher in the groups with higher MUAC than those in the group with lower MUAC (all P < 0.05). Pearson analysis showed that MUAC was correlated with BMI, WC, waist-to-hip ratio (WHR), logHOMA-IR, low density lipoprotein cholesterol (LDL-C), uric acid (UA) and high density lipoprotein cholesterol (HDL-C) in all subjects. Multivariate linear regression analysis revealed that MUAC was independently associated with logHOMA-IR (β = 0.036, P<0.001) after adjusting for age, gender, WHR, UA, TG, LDL-C and HDL-C. Binary logistic regression analysis revealed that MUAC was an independent predictor of central obesity (OR: 2.129, 95%CI: 1.311–3.457, P = 0.002). Furthermore, MUAC≥30.9cm for male and ≥30.0cm for female were the optimal cutoff values for identifying central obesity. CONCLUSIONS: Our study indicated that among Chinese subjects with type 2 diabetes, MUAC is a simple and effective tool for the determination of central obesity and IR. Additionally, the larger MUAC is proved to be more associated with metabolic risk factors of higher UA and LDL-C and lowever HDL-C.
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spelling pubmed-72417052020-06-08 Mid-upper arm circumference as a simple tool for identifying central obesity and insulin resistance in type 2 diabetes Zhu, Yanhua Lin, Qiongyan Zhang, Yao Deng, Hongrong Hu, Xiling Yang, Xubin Yao, Bin PLoS One Research Article BACKGROUND: Our research aimed to explore the correlation between mid-upper arm circumference (MUAC) and central obesity and insulin resistance (IR) in Chinese subjects with type 2 diabetes. MATERIALS: A total of 103 participants (60 men) were recruited in our study. MUAC was measured around the mid-arm between the shoulder and elbow. Waist circumference (WC) was obtained as central obesity parameter, and the IR parameter of Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) was calculated. The subjects were divided into three groups according to the tertiles cut-points of MUAC level. RESULTS: Body mass index (BMI), WC, the percentages of central obesity and HOMA-IR were significantly higher in the groups with higher MUAC than those in the group with lower MUAC (all P < 0.05). Pearson analysis showed that MUAC was correlated with BMI, WC, waist-to-hip ratio (WHR), logHOMA-IR, low density lipoprotein cholesterol (LDL-C), uric acid (UA) and high density lipoprotein cholesterol (HDL-C) in all subjects. Multivariate linear regression analysis revealed that MUAC was independently associated with logHOMA-IR (β = 0.036, P<0.001) after adjusting for age, gender, WHR, UA, TG, LDL-C and HDL-C. Binary logistic regression analysis revealed that MUAC was an independent predictor of central obesity (OR: 2.129, 95%CI: 1.311–3.457, P = 0.002). Furthermore, MUAC≥30.9cm for male and ≥30.0cm for female were the optimal cutoff values for identifying central obesity. CONCLUSIONS: Our study indicated that among Chinese subjects with type 2 diabetes, MUAC is a simple and effective tool for the determination of central obesity and IR. Additionally, the larger MUAC is proved to be more associated with metabolic risk factors of higher UA and LDL-C and lowever HDL-C. Public Library of Science 2020-05-21 /pmc/articles/PMC7241705/ /pubmed/32437358 http://dx.doi.org/10.1371/journal.pone.0231308 Text en © 2020 Zhu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhu, Yanhua
Lin, Qiongyan
Zhang, Yao
Deng, Hongrong
Hu, Xiling
Yang, Xubin
Yao, Bin
Mid-upper arm circumference as a simple tool for identifying central obesity and insulin resistance in type 2 diabetes
title Mid-upper arm circumference as a simple tool for identifying central obesity and insulin resistance in type 2 diabetes
title_full Mid-upper arm circumference as a simple tool for identifying central obesity and insulin resistance in type 2 diabetes
title_fullStr Mid-upper arm circumference as a simple tool for identifying central obesity and insulin resistance in type 2 diabetes
title_full_unstemmed Mid-upper arm circumference as a simple tool for identifying central obesity and insulin resistance in type 2 diabetes
title_short Mid-upper arm circumference as a simple tool for identifying central obesity and insulin resistance in type 2 diabetes
title_sort mid-upper arm circumference as a simple tool for identifying central obesity and insulin resistance in type 2 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241705/
https://www.ncbi.nlm.nih.gov/pubmed/32437358
http://dx.doi.org/10.1371/journal.pone.0231308
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