Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease

Prions are transmissible agents causing lethal neurodegenerative diseases that are composed of aggregates of misfolded cellular prion protein (PrP(Sc)). Despite non-fibrillar oligomers having been proposed as the most infectious prion particles, prions purified from diseased brains usually consist o...

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Detalles Bibliográficos
Autores principales: Vanni, Ilaria, Pirisinu, Laura, Acevedo-Morantes, Claudia, Kamali-Jamil, Razieh, Rathod, Vineet, Di Bari, Michele Angelo, D’Agostino, Claudia, Marcon, Stefano, Esposito, Elena, Riccardi, Geraldina, Hornemann, Simone, Senatore, Assunta, Aguzzi, Adriano, Agrimi, Umberto, Wille, Holger, Nonno, Romolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241950/
https://www.ncbi.nlm.nih.gov/pubmed/32303068
http://dx.doi.org/10.1093/brain/awaa078

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