Cargando…

Grading Ductal Carcinoma In Situ (DCIS) of the Breast – What’s Wrong with It?

Ductal carcinoma in situ of the breast is a non-obligate precursor of invasive breast cancer, and at its lower risk end might not need treatment, a hypothesis tested in several currently running randomized clinical trials. This review describes the heterogeneity of grading ductal carcinoma in situ (...

Descripción completa

Detalles Bibliográficos
Autores principales: Cserni, Gábor, Sejben, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242244/
https://www.ncbi.nlm.nih.gov/pubmed/31776839
http://dx.doi.org/10.1007/s12253-019-00760-8
_version_ 1783537203332251648
author Cserni, Gábor
Sejben, Anita
author_facet Cserni, Gábor
Sejben, Anita
author_sort Cserni, Gábor
collection PubMed
description Ductal carcinoma in situ of the breast is a non-obligate precursor of invasive breast cancer, and at its lower risk end might not need treatment, a hypothesis tested in several currently running randomized clinical trials. This review describes the heterogeneity of grading ductal carcinoma in situ (DCIS). First it considers differences between low and high grade DCIS, and then it looks at several grading schemes and highlights how different these are, not only in the features considered for defining a given grade but also in their wording of a given variable seen in the grade in question. Rather than being fully comprehensive, the review aims to illustrate the inconsistencies. Reproducibility studies on grading mostly suggestive of moderate agreement on DCIS differentiation are also illustrated. The need for a well structured, more uniform and widely accepted language for grading DCIS is urged to avoid misunderstanding based misclassifications and improper treatment selection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12253-019-00760-8) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-7242244
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-72422442020-06-03 Grading Ductal Carcinoma In Situ (DCIS) of the Breast – What’s Wrong with It? Cserni, Gábor Sejben, Anita Pathol Oncol Res Review Ductal carcinoma in situ of the breast is a non-obligate precursor of invasive breast cancer, and at its lower risk end might not need treatment, a hypothesis tested in several currently running randomized clinical trials. This review describes the heterogeneity of grading ductal carcinoma in situ (DCIS). First it considers differences between low and high grade DCIS, and then it looks at several grading schemes and highlights how different these are, not only in the features considered for defining a given grade but also in their wording of a given variable seen in the grade in question. Rather than being fully comprehensive, the review aims to illustrate the inconsistencies. Reproducibility studies on grading mostly suggestive of moderate agreement on DCIS differentiation are also illustrated. The need for a well structured, more uniform and widely accepted language for grading DCIS is urged to avoid misunderstanding based misclassifications and improper treatment selection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12253-019-00760-8) contains supplementary material, which is available to authorized users. Springer Netherlands 2019-11-27 2020 /pmc/articles/PMC7242244/ /pubmed/31776839 http://dx.doi.org/10.1007/s12253-019-00760-8 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Cserni, Gábor
Sejben, Anita
Grading Ductal Carcinoma In Situ (DCIS) of the Breast – What’s Wrong with It?
title Grading Ductal Carcinoma In Situ (DCIS) of the Breast – What’s Wrong with It?
title_full Grading Ductal Carcinoma In Situ (DCIS) of the Breast – What’s Wrong with It?
title_fullStr Grading Ductal Carcinoma In Situ (DCIS) of the Breast – What’s Wrong with It?
title_full_unstemmed Grading Ductal Carcinoma In Situ (DCIS) of the Breast – What’s Wrong with It?
title_short Grading Ductal Carcinoma In Situ (DCIS) of the Breast – What’s Wrong with It?
title_sort grading ductal carcinoma in situ (dcis) of the breast – what’s wrong with it?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242244/
https://www.ncbi.nlm.nih.gov/pubmed/31776839
http://dx.doi.org/10.1007/s12253-019-00760-8
work_keys_str_mv AT csernigabor gradingductalcarcinomainsitudcisofthebreastwhatswrongwithit
AT sejbenanita gradingductalcarcinomainsitudcisofthebreastwhatswrongwithit