miR-370 Sensitizes TMZ Response Dependent of MGMT Status in Primary Central Nervous System Lymphoma

Primary central nervous system lymphoma (PCNSL) is an aggressive and rare subtype of non-Hodgkin lymphoma, arising exclusively in the CNS with a poor prognosis. Previous evidence has proved that MGMT was a promising target involving in TMZ resistance of PCNSL. Our study described a new miR-370-media...

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Detalles Bibliográficos
Autores principales: Li, Xinwei, Xu, Xueying, Chen, Keng, Wu, Haijian, Wang, Yirong, Yang, Shuxu, Wang, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242252/
https://www.ncbi.nlm.nih.gov/pubmed/30712191
http://dx.doi.org/10.1007/s12253-019-00605-4
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author Li, Xinwei
Xu, Xueying
Chen, Keng
Wu, Haijian
Wang, Yirong
Yang, Shuxu
Wang, Kun
author_facet Li, Xinwei
Xu, Xueying
Chen, Keng
Wu, Haijian
Wang, Yirong
Yang, Shuxu
Wang, Kun
author_sort Li, Xinwei
collection PubMed
description Primary central nervous system lymphoma (PCNSL) is an aggressive and rare subtype of non-Hodgkin lymphoma, arising exclusively in the CNS with a poor prognosis. Previous evidence has proved that MGMT was a promising target involving in TMZ resistance of PCNSL. Our study described a new miR-370-mediated mechanism of MGMT regulation in PCNSL. We first showed that miR-370 was downregulated in PCNSL tissues, while MGMT was inversely overexpressed. It was also observed that miR-370 suppressed the expression of MGMT. Additionally, upregulation of miR-370 significantly increased TMZ sensitivity dependent of MGMT, thus suppressed Raji cell proliferation and induced apoptosis in vitro. In conclusion, these results suggest that miR-370 is a potential target in PCNSL treatment.
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spelling pubmed-72422522020-06-03 miR-370 Sensitizes TMZ Response Dependent of MGMT Status in Primary Central Nervous System Lymphoma Li, Xinwei Xu, Xueying Chen, Keng Wu, Haijian Wang, Yirong Yang, Shuxu Wang, Kun Pathol Oncol Res Original Article Primary central nervous system lymphoma (PCNSL) is an aggressive and rare subtype of non-Hodgkin lymphoma, arising exclusively in the CNS with a poor prognosis. Previous evidence has proved that MGMT was a promising target involving in TMZ resistance of PCNSL. Our study described a new miR-370-mediated mechanism of MGMT regulation in PCNSL. We first showed that miR-370 was downregulated in PCNSL tissues, while MGMT was inversely overexpressed. It was also observed that miR-370 suppressed the expression of MGMT. Additionally, upregulation of miR-370 significantly increased TMZ sensitivity dependent of MGMT, thus suppressed Raji cell proliferation and induced apoptosis in vitro. In conclusion, these results suggest that miR-370 is a potential target in PCNSL treatment. Springer Netherlands 2019-02-02 2020 /pmc/articles/PMC7242252/ /pubmed/30712191 http://dx.doi.org/10.1007/s12253-019-00605-4 Text en © Arányi Lajos Foundation 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Li, Xinwei
Xu, Xueying
Chen, Keng
Wu, Haijian
Wang, Yirong
Yang, Shuxu
Wang, Kun
miR-370 Sensitizes TMZ Response Dependent of MGMT Status in Primary Central Nervous System Lymphoma
title miR-370 Sensitizes TMZ Response Dependent of MGMT Status in Primary Central Nervous System Lymphoma
title_full miR-370 Sensitizes TMZ Response Dependent of MGMT Status in Primary Central Nervous System Lymphoma
title_fullStr miR-370 Sensitizes TMZ Response Dependent of MGMT Status in Primary Central Nervous System Lymphoma
title_full_unstemmed miR-370 Sensitizes TMZ Response Dependent of MGMT Status in Primary Central Nervous System Lymphoma
title_short miR-370 Sensitizes TMZ Response Dependent of MGMT Status in Primary Central Nervous System Lymphoma
title_sort mir-370 sensitizes tmz response dependent of mgmt status in primary central nervous system lymphoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242252/
https://www.ncbi.nlm.nih.gov/pubmed/30712191
http://dx.doi.org/10.1007/s12253-019-00605-4
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