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Understanding Concomitant Physical and Chemical Transformations of Simvastatin During Dry Ball Milling
The present study investigates concomitant processes of solid-state disordering and oxidation of simvastatin during milling. The separate dry ball milling of crystalline and amorphous powders of simvastatin were conducted at ambient temperature for 10 and 60 min each. The relative crystallinity was...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242262/ https://www.ncbi.nlm.nih.gov/pubmed/32440782 http://dx.doi.org/10.1208/s12249-020-01687-z |