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Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review

The solid-pseudopapillary neoplasm of the pancreas is a rare but enigmatic entity occurring mainly in young women. Since the first description by V. Frantz in 1959 the terminology of this tumor has continuously changed but it has remained simply descriptive, because the exact histogenesis is still o...

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Detalles Bibliográficos
Autores principales: Zalatnai, Attila, Kis-Orha, Viktória
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242268/
https://www.ncbi.nlm.nih.gov/pubmed/31209654
http://dx.doi.org/10.1007/s12253-019-00671-8
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author Zalatnai, Attila
Kis-Orha, Viktória
author_facet Zalatnai, Attila
Kis-Orha, Viktória
author_sort Zalatnai, Attila
collection PubMed
description The solid-pseudopapillary neoplasm of the pancreas is a rare but enigmatic entity occurring mainly in young women. Since the first description by V. Frantz in 1959 the terminology of this tumor has continuously changed but it has remained simply descriptive, because the exact histogenesis is still obscure. Although in majority of cases the survival is excellent, nevertheless, the expected prognosis is not exactly predictable. In this review the authors aim to summarize its clinico-pathological features, the expected biological behavior, the molecular alterations, the immune phenotype and discuss the putative histogenesis. From diagnostic point of view, the salient histological characteristic findings are analyzed that would help to differentiate it from other, look-alike pancreatic tumors, and suggestions are made about the desirable content of the histological report.
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spelling pubmed-72422682020-06-03 Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review Zalatnai, Attila Kis-Orha, Viktória Pathol Oncol Res Review The solid-pseudopapillary neoplasm of the pancreas is a rare but enigmatic entity occurring mainly in young women. Since the first description by V. Frantz in 1959 the terminology of this tumor has continuously changed but it has remained simply descriptive, because the exact histogenesis is still obscure. Although in majority of cases the survival is excellent, nevertheless, the expected prognosis is not exactly predictable. In this review the authors aim to summarize its clinico-pathological features, the expected biological behavior, the molecular alterations, the immune phenotype and discuss the putative histogenesis. From diagnostic point of view, the salient histological characteristic findings are analyzed that would help to differentiate it from other, look-alike pancreatic tumors, and suggestions are made about the desirable content of the histological report. Springer Netherlands 2019-06-17 2020 /pmc/articles/PMC7242268/ /pubmed/31209654 http://dx.doi.org/10.1007/s12253-019-00671-8 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Zalatnai, Attila
Kis-Orha, Viktória
Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review
title Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review
title_full Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review
title_fullStr Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review
title_full_unstemmed Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review
title_short Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review
title_sort solid-pseudopapillary neoplasms of the pancreas is still an enigma: a clinicopathological review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242268/
https://www.ncbi.nlm.nih.gov/pubmed/31209654
http://dx.doi.org/10.1007/s12253-019-00671-8
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