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Preliminary Study on Selected Markers of Oxidative Stress, Inflammation and Angiogenesis in Patients with Bladder Cancer

In recent years, bladder cancer (BC) has been reported as one of the most commonly occurring cancers among older people, and its detection is still difficult. Therefore, there is a need to search for additional useful markers of disease. Some studies indicate the important roles of inflammation and...

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Autores principales: Sawicka, Ewa, Kratz, Ewa Maria, Szymańska, Beata, Guzik, Anna, Wesołowski, Artur, Kowal, Paweł, Pawlik-Sobecka, Lilla, Piwowar, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242270/
https://www.ncbi.nlm.nih.gov/pubmed/30828780
http://dx.doi.org/10.1007/s12253-019-00620-5
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author Sawicka, Ewa
Kratz, Ewa Maria
Szymańska, Beata
Guzik, Anna
Wesołowski, Artur
Kowal, Paweł
Pawlik-Sobecka, Lilla
Piwowar, Agnieszka
author_facet Sawicka, Ewa
Kratz, Ewa Maria
Szymańska, Beata
Guzik, Anna
Wesołowski, Artur
Kowal, Paweł
Pawlik-Sobecka, Lilla
Piwowar, Agnieszka
author_sort Sawicka, Ewa
collection PubMed
description In recent years, bladder cancer (BC) has been reported as one of the most commonly occurring cancers among older people, and its detection is still difficult. Therefore, there is a need to search for additional useful markers of disease. Some studies indicate the important roles of inflammation and oxidative stress (OS) in bladder tumour pathogenesis. The aim of this study was to examine the levels of selected markers of OS, inflammation and angiogenesis in blood plasma/serum samples derived from patients with BC, and a healthy control group. Moreover the degrees of change and strength of correlation between values of the analysed markers and tumour stage or grade were estimated. Concentrations of: malondialdehyde (MDA) and advanced oxidation protein products (AOPP), and total antioxidant status (TAS) divided into slow (TAS-s) and fast (TAS-f) antioxidants (spectrophotometric measurement), angiogenin (ANG) (immunoenzymatic method) and C-reactive protein (CRP) (immunoturbidimetric method) were determined in both the studied groups. The majority of values of the examined parameters were significantly higher among patients, while subfractions of TAS were significantly lower in comparison to the control group. Moreover, different values and different strengths of correlation between the examined parameters and cancer stage or grade were noticed. The most significant changes for CRP were observed in T2 and for MDA in G3, while the lowest TAS-f activity was revealed in G1 patients. Increased values of OS parameters, angiogenesis and inflammation markers, in combination with reduced TAS subfractions activity in BC are important in its pathogenesis and will be helpful in estimation of patients’ condition.
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spelling pubmed-72422702020-06-03 Preliminary Study on Selected Markers of Oxidative Stress, Inflammation and Angiogenesis in Patients with Bladder Cancer Sawicka, Ewa Kratz, Ewa Maria Szymańska, Beata Guzik, Anna Wesołowski, Artur Kowal, Paweł Pawlik-Sobecka, Lilla Piwowar, Agnieszka Pathol Oncol Res Original Article In recent years, bladder cancer (BC) has been reported as one of the most commonly occurring cancers among older people, and its detection is still difficult. Therefore, there is a need to search for additional useful markers of disease. Some studies indicate the important roles of inflammation and oxidative stress (OS) in bladder tumour pathogenesis. The aim of this study was to examine the levels of selected markers of OS, inflammation and angiogenesis in blood plasma/serum samples derived from patients with BC, and a healthy control group. Moreover the degrees of change and strength of correlation between values of the analysed markers and tumour stage or grade were estimated. Concentrations of: malondialdehyde (MDA) and advanced oxidation protein products (AOPP), and total antioxidant status (TAS) divided into slow (TAS-s) and fast (TAS-f) antioxidants (spectrophotometric measurement), angiogenin (ANG) (immunoenzymatic method) and C-reactive protein (CRP) (immunoturbidimetric method) were determined in both the studied groups. The majority of values of the examined parameters were significantly higher among patients, while subfractions of TAS were significantly lower in comparison to the control group. Moreover, different values and different strengths of correlation between the examined parameters and cancer stage or grade were noticed. The most significant changes for CRP were observed in T2 and for MDA in G3, while the lowest TAS-f activity was revealed in G1 patients. Increased values of OS parameters, angiogenesis and inflammation markers, in combination with reduced TAS subfractions activity in BC are important in its pathogenesis and will be helpful in estimation of patients’ condition. Springer Netherlands 2019-03-04 2020 /pmc/articles/PMC7242270/ /pubmed/30828780 http://dx.doi.org/10.1007/s12253-019-00620-5 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Sawicka, Ewa
Kratz, Ewa Maria
Szymańska, Beata
Guzik, Anna
Wesołowski, Artur
Kowal, Paweł
Pawlik-Sobecka, Lilla
Piwowar, Agnieszka
Preliminary Study on Selected Markers of Oxidative Stress, Inflammation and Angiogenesis in Patients with Bladder Cancer
title Preliminary Study on Selected Markers of Oxidative Stress, Inflammation and Angiogenesis in Patients with Bladder Cancer
title_full Preliminary Study on Selected Markers of Oxidative Stress, Inflammation and Angiogenesis in Patients with Bladder Cancer
title_fullStr Preliminary Study on Selected Markers of Oxidative Stress, Inflammation and Angiogenesis in Patients with Bladder Cancer
title_full_unstemmed Preliminary Study on Selected Markers of Oxidative Stress, Inflammation and Angiogenesis in Patients with Bladder Cancer
title_short Preliminary Study on Selected Markers of Oxidative Stress, Inflammation and Angiogenesis in Patients with Bladder Cancer
title_sort preliminary study on selected markers of oxidative stress, inflammation and angiogenesis in patients with bladder cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242270/
https://www.ncbi.nlm.nih.gov/pubmed/30828780
http://dx.doi.org/10.1007/s12253-019-00620-5
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