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Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease
Monoamine oxidase type B inhibitors act in Parkinson’s disease (PD) via potentiation of dopamine, but may also have neuroprotective effects by reducing oxidative damage. Oxidative damage is also a feature of environmental toxins, including pesticides, that are an established risk factor for PD. Anot...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242276/ https://www.ncbi.nlm.nih.gov/pubmed/31836905 http://dx.doi.org/10.1007/s00702-019-02119-4 |
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author | Liu, Hanxiang Wei, Xianwen Yang, Wen Reynolds, Gavin P. |
author_facet | Liu, Hanxiang Wei, Xianwen Yang, Wen Reynolds, Gavin P. |
author_sort | Liu, Hanxiang |
collection | PubMed |
description | Monoamine oxidase type B inhibitors act in Parkinson’s disease (PD) via potentiation of dopamine, but may also have neuroprotective effects by reducing oxidative damage. Oxidative damage is also a feature of environmental toxins, including pesticides, that are an established risk factor for PD. Another risk factor is low circulating uric acid (UA), which may relate to UA being the major endogenous antioxidant in the human body. We have undertaken a study of 192 initial admissions for PD in a general hospital neurology department in a partly rural region of Southern China to determine if there is an increased rate of PD in agricultural workers who have a high risk of exposure to pesticides, and how it may relate to deficits in UA. We found a disproportionately high number of agricultural workers admitted with PD (66.7% vs. 54.3% of all neurology admissions) and that PD subjects have a substantial reduction in UA. This is further reduced in agricultural workers and thus may contribute to the increased vulnerability of this group to PD. |
format | Online Article Text |
id | pubmed-7242276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-72422762020-06-03 Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease Liu, Hanxiang Wei, Xianwen Yang, Wen Reynolds, Gavin P. J Neural Transm (Vienna) Neurology and Preclinical Neurological Studies - Original Article Monoamine oxidase type B inhibitors act in Parkinson’s disease (PD) via potentiation of dopamine, but may also have neuroprotective effects by reducing oxidative damage. Oxidative damage is also a feature of environmental toxins, including pesticides, that are an established risk factor for PD. Another risk factor is low circulating uric acid (UA), which may relate to UA being the major endogenous antioxidant in the human body. We have undertaken a study of 192 initial admissions for PD in a general hospital neurology department in a partly rural region of Southern China to determine if there is an increased rate of PD in agricultural workers who have a high risk of exposure to pesticides, and how it may relate to deficits in UA. We found a disproportionately high number of agricultural workers admitted with PD (66.7% vs. 54.3% of all neurology admissions) and that PD subjects have a substantial reduction in UA. This is further reduced in agricultural workers and thus may contribute to the increased vulnerability of this group to PD. Springer Vienna 2019-12-14 2020 /pmc/articles/PMC7242276/ /pubmed/31836905 http://dx.doi.org/10.1007/s00702-019-02119-4 Text en © The Author(s) 2019 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Neurology and Preclinical Neurological Studies - Original Article Liu, Hanxiang Wei, Xianwen Yang, Wen Reynolds, Gavin P. Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease |
title | Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease |
title_full | Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease |
title_fullStr | Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease |
title_full_unstemmed | Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease |
title_short | Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease |
title_sort | agricultural work and reduced circulating uric acid are both associated with initial hospital admission for parkinson’s disease |
topic | Neurology and Preclinical Neurological Studies - Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242276/ https://www.ncbi.nlm.nih.gov/pubmed/31836905 http://dx.doi.org/10.1007/s00702-019-02119-4 |
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