Correction of the tumor suppressor Salvador homolog-1 deficiency in tumors by lycorine as a new strategy in lung cancer therapy

Salvador homolog-1 (SAV1) is a tumor suppressor required for activation of the tumor-suppressive Hippo pathway and inhibition of tumorigenesis. SAV1 is defective in several cancer types. SAV1 deficiency in cells promotes tumorigenesis and cancer metastasis, and is closely associated with poor progno...

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Detalles Bibliográficos
Autores principales: Zhao, Zhe, Xiang, Shufen, Qi, Jindan, Wei, Yijun, Zhang, Mengli, Yao, Jun, Zhang, Tong, Meng, Mei, Wang, Xiaohua, Zhou, Quansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242319/
https://www.ncbi.nlm.nih.gov/pubmed/32439835
http://dx.doi.org/10.1038/s41419-020-2591-0

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