Cargando…

Stability and Activity of the Hyperglycosylated Human Interferon-β R27T Variant

A hyperglycosylated recombinant human interferon-β (rhIFN-β) R27T mutant was established to improve relapsing-remitting multiple sclerosis (RRMS) in our previous study. We focused on the stability of the R27T mutant throughout its production lifetime, including culture, purification, and storage bef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Kyoung, Moon, Dae Bong, Kim, Na Young, Shin, Young Kee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242330/ https://www.ncbi.nlm.nih.gov/pubmed/32439982 http://dx.doi.org/10.1038/s41598-020-65495-y

Ejemplares similares

Glycosylation Heterogeneity of Hyperglycosylated Recombinant Human Interferon-β (rhIFN-β)
por: Song, Kyoung, et al.
Publicado: (2020)

Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization
por: Thornlow, Dana N., et al.
Publicado: (2021)

Transient hyperglycosylation of rhodopsin with galactose
por: Smith, Sylvia B., et al.
Publicado: (1991)

A Glycoengineered Interferon-β Mutein (R27T) Generates Prolonged Signaling by an Altered Receptor-Binding Kinetics
por: Lee, Saehyung, et al.
Publicado: (2019)

Insights into the hyperglycosylation of human chorionic gonadotropin revealed by glycomics analysis
por: Ibeto, Linda, et al.
Publicado: (2020)

Semiprocessive Hyperglycosylation of Adhesin by Bacterial Protein N-Glycosyltransferases
por: Yakovlieva, Liubov, et al.
Publicado: (2021)

Hyperglycosylated resurfaced stabilized GP120 core as an immunogen elicits antibodies targeted at the CD4-binding site
por: Dai, K, et al.
Publicado: (2012)

Differences in the production of hyperglycosylated IFN alpha in CHO and HEK 293 cells
por: Gugliotta, Agustina, et al.
Publicado: (2013)

OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation
por: Dersh, Devin, et al.
Publicado: (2014)

Transgenic Overexpression of LARGE Induces α-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle
por: Brockington, Martin, et al.
Publicado: (2010)

Hyperglycosylated-hCG: Its Role in Trophoblast Invasion and Intrauterine Growth Restriction
por: Herghelegiu, Catalin Gabriel, et al.
Publicado: (2023)

A medium hyperglycosylated podocalyxin enables noninvasive and quantitative detection of tumorigenic human pluripotent stem cells
por: Tateno, Hiroaki, et al.
Publicado: (2014)

In silico design and analysis of a new hyperglycosylated analog of erythropoietin to improve drug efficacy
por: Kianmehr, Anvarsadat, et al.
Publicado: (2015)

Prediction of pre-eclampsia and its subtypes in high-risk cohort: hyperglycosylated human chorionic gonadotropin in multivariate models
por: Murtoniemi, Katja, et al.
Publicado: (2018)

Migrating endothelial cells are distinctly hyperglycosylated and express specific migration-associated cell surface glycoproteins
Publicado: (1992)

Sensitization of glycoengineered interferon-β1a-resistant cancer cells by cFLIP inhibition for enhanced anti-cancer therapy
por: Kim, Tae-Eun, et al.
Publicado: (2017)

A novel mouse model of CMT1B identifies hyperglycosylation as a new pathogenetic mechanism
por: Veneri, Francesca A, et al.
Publicado: (2022)

Glycoengineering of Interferon-β 1a Improves Its Biophysical and Pharmacokinetic Properties
por: Song, Kyoung, et al.
Publicado: (2014)

First trimester serum placental growth factor and hyperglycosylated human chorionic gonadotropin are associated with pre-eclampsia: a case control study
por: Keikkala, Elina, et al.
Publicado: (2016)

A Novel Insertion in the Hepatitis B Virus Surface Protein Leading to Hyperglycosylation Causes Diagnostic and Immune Escape
por: Lehmann, Felix, et al.
Publicado: (2023)

Periconception onset diabetes is associated with embryopathy and fetal growth retardation, reproductive tract hyperglycosylation and impaired immune adaptation to pregnancy
por: Brown, Hannah M., et al.
Publicado: (2018)

Hyperglycosylated gp120 mutants elicit improved CD4-binding site directed antibodies in a heterologous prime:boost regimen
por: Ahmed, FK, et al.
Publicado: (2012)

Direct Detection of Glycated Human Serum Albumin and Hyperglycosylated IgG3 in Serum, by MALDI-ToF Mass Spectrometry, as a Predictor of COVID-19 Severity
por: Iles, Ray K., et al.
Publicado: (2022)

The sensitivity and specificity of hyperglycosylated hCG (hhCG) levels to reliably diagnose clinical IVF pregnancies at 6 days following embryo transfer
por: Strom, Charles M., et al.
Publicado: (2012)

The incC Sequence Is Required for R27 Plasmid Stability
por: Tassinari, Eleonora, et al.
Publicado: (2016)

Broader Neutralizing Antibodies against H5N1 Viruses Using Prime-Boost Immunization of Hyperglycosylated Hemagglutinin DNA and Virus-Like Particles
por: Lin, Shih-Chang, et al.
Publicado: (2012)

Antiviral Activities of Interleukin-27: A Partner for Interferons?
por: Amsden, Heather, et al.
Publicado: (2022)

Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus
por: Vo, Mai Tram, et al.
Publicado: (2019)

Interferon β protects against avascular osteonecrosis through interleukin 6 inhibition and silent information regulator transcript-1 upregulation
por: Kim, Kyoung Min, et al.
Publicado: (2017)

Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2
por: Xing, Yushu, et al.
Publicado: (2023)

The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits
por: Moon, Sanghoon, et al.
Publicado: (2019)

Bim Nuclear Translocation and Inactivation by Viral Interferon Regulatory Factor
por: Choi, Young Bong, et al.
Publicado: (2010)

JNK‐mediated Ser27 phosphorylation and stabilization of SIRT1 promote growth and progression of colon cancer through deacetylation‐dependent activation of Snail
por: Lee, Yeon‐Hwa, et al.
Publicado: (2022)

FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas
por: Kim, Kyoung Min, et al.
Publicado: (2019)

Interferon alpha-inducible protein 27 (IFI27) is a prognostic marker for pancreatic cancer based on comprehensive bioinformatics analysis
por: Huang, Shu, et al.
Publicado: (2021)

Case report: Cerebrotendinous xanthomatosis with a novel mutation in the CYP27A1 gene mimicking behavioral variant frontotemporal dementia
por: Chun, Min Young, et al.
Publicado: (2023)

The Comparison Between the Mutated HuIFN-β 27-101 and the Wild Type Interferon β: the Comprehensive In Silico Study to Evaluate the Effect of Mutations on IFN-β
por: Balkhi, Sayed Sharif, et al.
Publicado: (2019)

Methylation profile of hepatitis B virus is not influenced by interferon α in human liver cancer cells
por: Moon, In Young, et al.
Publicado: (2021)

Enhancement of Cytotoxicity of Cisplatin in vitro by Recombinant Human Tumor Necrosis Factor and/or Recombinant Human Interferon‐α, β and ‐γ
por: Kim, Chang‐Min, et al.
Publicado: (1989)

Human Rhinovirus-induced Proinflammatory Cytokine and Interferon-β Responses in Nasal Epithelial Cells From Chronic Rhinosinusitis Patients
por: Kim, Ji Heui, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_alor5mv5c72l1jlv8fd8e6mlv9