Inhibition of soluble epoxide hydrolase attenuates renal tubular mitochondrial dysfunction and ER stress by restoring autophagic flux in diabetic nephropathy

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD), and renal tubular cell dysfunction contributes to the pathogenesis of DN. Soluble epoxide hydrolase (sEH) is an enzyme that can hydrolyze epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids (EpFAs) into the le...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Xu-shun, Xiang, Xing-yang, Chen, Xue-mei, He, Jun-ling, Liu, Ting, Gan, Hua, Du, Xiao-gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242354/
https://www.ncbi.nlm.nih.gov/pubmed/32439839
http://dx.doi.org/10.1038/s41419-020-2594-x

Ejemplares similares

Ejemplares similares