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Decreased Na(+)/K(+) ATPase Expression and Depolarized Cell Membrane in Neurons Differentiated from Chorea-Acanthocytosis Patients

Loss of function mutations of the chorein-encoding gene VPS13A lead to chorea-acanthocytosis (ChAc), a neurodegenerative disorder with accelerated suicidal neuronal cell death, which could be reversed by lithium. Chorein upregulates the serum and glucocorticoid inducible kinase SGK1. Targets of SGK1...

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Detalles Bibliográficos
Autores principales:	Hosseinzadeh, Zohreh, Hauser, Stefan, Singh, Yogesh, Pelzl, Lisann, Schuster, Stefanie, Sharma, Yamini, Höflinger, Philip, Zacharopoulou, Nefeli, Stournaras, Christos, Rathbun, Daniel L., Zrenner, Eberhart, Schöls, Ludger, Lang, Florian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242441/ https://www.ncbi.nlm.nih.gov/pubmed/32439941 http://dx.doi.org/10.1038/s41598-020-64845-0

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