Cargando…

Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy

Toll-like receptors (TLRs) play crucial roles in host immune defenses. Recently, TLR-mediated autophagy is reported to promote immune responses via increasing antigen processing and presentation in antigen presenting cells. The present study examined whether the synthetic TLR4 activator (CCL-34) cou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chou, Yi-Ju, Lin, Ching-Cheng, Dzhagalov, Ivan, Chen, Nien-Jung, Lin, Chao-Hsiung, Lin, Chun-Cheng, Chen, Szu-Ting, Chen, Kuo-Hsin, Fu, Shu-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242473/ https://www.ncbi.nlm.nih.gov/pubmed/32439945 http://dx.doi.org/10.1038/s41598-020-65422-1

Ejemplares similares

Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity
por: Facchini, Fabio A., et al.
Publicado: (2021)

A SYNTHETIC GLYCOLIPID WITH B-CELL MITOGENIC ACTIVITY
por: Rosenstreich, David L., et al.
Publicado: (1974)

Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages
por: Palmer, Charys, et al.
Publicado: (2021)

Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents
por: Carreño, Leandro J, et al.
Publicado: (2016)

The synthetic glycolipid-based TLR4 antagonist FP7 negatively regulates in vitro and in vivo haematopoietic and non-haematopoietic vascular TLR4 signalling
por: Palmer, Charys, et al.
Publicado: (2018)

Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo
por: Huber, Alexandra, et al.
Publicado: (2016)

Synthetic Phenolic Glycolipids for Application in Diagnostic Tests for Leprosy
por: van Dijk, J. Hessel M., et al.
Publicado: (2021)

Clitocybe nuda Activates Dendritic Cells and Acts as a DNA Vaccine Adjuvant
por: Chen, Mei-Hsing, et al.
Publicado: (2013)

Chemistry and Biology of Bioactive Glycolipids of Marine Origin
por: Cheng-Sánchez, Iván, et al.
Publicado: (2018)

Development of a novel mechanism-based glycolipid adjuvant for vaccination
por: Coelho-dos-Reis, Jordana Grazziela, et al.
Publicado: (2018)

Sulfated archaeol glycolipids: Comparison with other immunological adjuvants in mice
por: Akache, Bassel, et al.
Publicado: (2018)

Effects of structural variations in synthetic glycolipids upon mitogenicity for spleen lymphocytes, adjuvancy for humoral immune response and on anti-tumour potential.
por: Nigam, V. N., et al.
Publicado: (1982)

Atorvastatin Attenuates Radiotherapy-Induced Intestinal Damage through Activation of Autophagy and Antioxidant Effects
por: Wei, Ming-Feng, et al.
Publicado: (2022)

A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction
por: Wu, Chun-Hsien, et al.
Publicado: (2020)

Differences in the outcomes of adjuvant chemotherapy for colon cancer prescribed by physicians in different disciplines: a population-based study in Taiwan
por: Hsieh, Cheng-I, et al.
Publicado: (2018)

Co‐administration of Antimicrobial Peptides Enhances Toll‐like Receptor 4 Antagonist Activity of a Synthetic Glycolipid
por: Facchini, Fabio A., et al.
Publicado: (2018)

Corrigendum: A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction
por: Wu, Chun-Hsien, et al.
Publicado: (2021)

Contributions of Glycolipid Biosurfactants and Glycolipid-Modified Materials to Antimicrobial Strategy: A Review
por: Shu, Qin, et al.
Publicado: (2021)

Discoidin Domain Receptors 1 Inhibition Alleviates Osteoarthritis via Enhancing Autophagy
por: Chou, Hsin-Chaio, et al.
Publicado: (2020)

Mirror Illusion Modulates M1 Activities and Functional Connectivity Patterns of Perceptual–Attention Circuits During Bimanual Movements: A Magnetoencephalography Study
por: Cheng, Chia-Hsiung, et al.
Publicado: (2020)

Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages
por: Oldenburg, Reid, et al.
Publicado: (2018)

Dehydroeburicoic Acid from Antrodia camphorata Prevents the Diabetic and Dyslipidemic State via Modulation of Glucose Transporter 4, Peroxisome Proliferator-Activated Receptor α Expression and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice
por: Kuo, Yueh-Hsiung, et al.
Publicado: (2016)

Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach
por: Fox, Christopher B., et al.
Publicado: (2016)

Antidiabetic and Immunoregulatory Activities of Extract of Phyllanthus emblica L. in NOD with Spontaneous and Cyclophosphamide-Accelerated Diabetic Mice
por: Lin, Cheng-Hsiu, et al.
Publicado: (2023)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo
por: Lee, Ying-Ray, et al.
Publicado: (2018)

Plasma-activated medium as adjuvant therapy for lung cancer with malignant pleural effusion
por: Cheng, Yi-Jing, et al.
Publicado: (2020)

Wogonin Improves Histological and Functional Outcomes, and Reduces Activation of TLR4/NF-κB Signaling after Experimental Traumatic Brain Injury
por: Chen, Chien-Cheng, et al.
Publicado: (2012)

Synthetic analogs of an Entamoeba histolytica glycolipid designed to combat intracellular Leishmania infection
por: Choy, Siew Ling, et al.
Publicado: (2017)

SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6
por: Li, Shih-Wen, et al.
Publicado: (2016)

Integrative network analysis reveals active microRNAs and their functions in gastric cancer
por: Tseng, Chien-Wei, et al.
Publicado: (2011)

Correction: Wogonin Improves Histological and Functional Outcomes, and Reduces Activation of TLR4/NF-κB Signaling after Experimental Traumatic Brain Injury
por: Chen, Chien-Cheng, et al.
Publicado: (2012)

Effects of Bofu-Tsusho-San on Diabetes and Hyperlipidemia Associated with AMP-Activated Protein Kinase and Glucose Transporter 4 in High-Fat-Fed Mice
por: Lin, Cheng-Hsiu, et al.
Publicado: (2014)

Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation
por: Chen, I-Ting, et al.
Publicado: (2015)

HMGCS2 enhances invasion and metastasis via direct interaction with PPARα to activate Src signaling in colorectal cancer and oral cancer
por: Chen, Shih-Wen, et al.
Publicado: (2016)

Schistosoma japonicum infection causes a reprogramming of glycolipid metabolism in the liver
por: Xu, Zhi-Peng, et al.
Publicado: (2019)

TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension
por: Yeh, Fu-Chiang, et al.
Publicado: (2023)

Thymic macrophages consist of two populations with distinct localization and origin
por: Zhou, Tyng-An, et al.
Publicado: (2022)

Antidiabetic and hypolipidemic activities of eburicoic acid, a triterpenoid compound from Antrodia camphorata, by regulation of Akt phosphorylation, gluconeogenesis, and PPARα in streptozotocin-induced diabetic mice
por: Lin, Cheng-Hsiu, et al.
Publicado: (2018)

Ablation of Discoidin Domain Receptor 1 Provokes an Osteopenic Phenotype by Regulating Osteoblast/Osteocyte Autophagy and Apoptosis
por: Chou, Hsin-Chiao, et al.
Publicado: (2022)

Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice
por: Lin, Hui-Tsu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_amav0iulujvcsrhi0fpicn8tdv