Thermodynamic interference with bile acid demicelleization reduces systemic entry and injury during cholestasis

Bile acids (BA), with their large hydrophobic steroid nucleus and polar groups are amphipathic molecules. In bile, these exist as micelles above their critical micellar concentration (CMC). In blood at low concentrations, these exist as monomers, initiating cellular signals. This micellar to monomer...

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Detalles Bibliográficos
Autores principales: de Oliveira, Cristiane, Khatua, Biswajit, El-Kurdi, Bara, Patel, Krutika, Mishra, Vivek, Navina, Sarah, Grim, Bradley J., Gupta, Srishti, Belohlavek, Marek, Cherry, Brian, Yarger, Jeffery, Green, Matthew D., Singh, Vijay P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242474/
https://www.ncbi.nlm.nih.gov/pubmed/32439972
http://dx.doi.org/10.1038/s41598-020-65451-w

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