Reduced O-GlcNAcylation and tubular hypoxia contribute to the antifibrotic effect of SGLT2 inhibitor dapagliflozin in the diabetic kidney

Diabetic kidney disease is a worldwide epidemic, and therapies are incomplete. Clinical data suggest that improved renal outcomes by Na(+)-glucose cotransporter 2 inhibitor (SGLT2i) are partly beyond their antihyperglycemic effects; however, the mechanisms are still elusive. Here, we investigated th...

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Detalles Bibliográficos
Autores principales: Hodrea, Judit, Balogh, Dora B., Hosszu, Adam, Lenart, Lilla, Besztercei, Balazs, Koszegi, Sandor, Sparding, Nadja, Genovese, Federica, Wagner, Laszlo J., Szabo, Attila J., Fekete, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242633/
https://www.ncbi.nlm.nih.gov/pubmed/32116017
http://dx.doi.org/10.1152/ajprenal.00021.2020

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