Cargando…

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication of SARS-CoV-2 depends on the viral RNA-dependent RNA polymerase (RdRp), which is the likely target of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gordon, Calvin J., Tchesnokov, Egor P., Woolner, Emma, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Editors' Picks
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242698/ https://www.ncbi.nlm.nih.gov/pubmed/32284326 http://dx.doi.org/10.1074/jbc.RA120.013679

Ejemplares similares

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
por: Gordon, Calvin J., et al.
Publicado: (2020)

Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
por: Tchesnokov, Egor P., et al.
Publicado: (2020)

Correction: Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
por: Tchesnokov, Egor P., et al.
Publicado: (2021)

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
por: Tchesnokov, Egor P., et al.
Publicado: (2019)

Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir
por: Gordon, Calvin J., et al.
Publicado: (2021)

Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs
por: Maheden, Kieran, et al.
Publicado: (2021)

Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms
por: Stevens, Laura J., et al.
Publicado: (2022)

Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus
por: Tchesnokov, Egor P., et al.
Publicado: (2018)

Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template
por: Gordon, Calvin J., et al.
Publicado: (2021)

Halting coronavirus polymerase
por: Kirchdoerfer, Robert N.
Publicado: (2020)

Sandacrabins – Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium
por: Bader, Chantal D., et al.
Publicado: (2022)

Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases
por: Lo, Michael K., et al.
Publicado: (2020)

Molecular characterization of the RNA-protein complex directing −2/−1 programmed ribosomal frameshifting during arterivirus replicase expression
por: Patel, Ankoor, et al.
Publicado: (2021)

A unique structural domain in Methanococcoides burtonii ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) acts as a small subunit mimic
por: Gunn, Laura H., et al.
Publicado: (2017)

Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors
por: Chavali, Sai Shashank, et al.
Publicado: (2021)

Transcription factor-7–like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion
por: Nguyen-Tu, Marie-Sophie, et al.
Publicado: (2018)

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase
por: Brown, Ariane J., et al.
Publicado: (2019)

The Pros of changing tRNA identity
por: Ibba, Michael
Publicado: (2023)

Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein
por: Tchesnokov, Egor P., et al.
Publicado: (2020)

Structural and functional consequences of age-related isomerization in α-crystallins
por: Lyon, Yana A., et al.
Publicado: (2019)

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
por: Agostini, Maria L., et al.
Publicado: (2018)

Sisyphus observed: Unraveling the high ATP usage of an RNA chaperone
por: Duran, Elizabeth C., et al.
Publicado: (2021)

Major adverse cardiac event rates in moderate‐risk patients: Does prior coronary disease matter?
por: McGinnis, Henderson D., et al.
Publicado: (2022)

Decoding the impact of disease-causing mutations in an essential aminoacyl-tRNA synthetase
por: Sissler, Marie
Publicado: (2021)

Archeal tRNA meets biotechnology: From vaccines to genetic code expansion
por: Ribas de Pouplana, Lluís
Publicado: (2022)

Pumping the brakes: A noncanonical RNA-binding domain in FMRP stalls elongating ribosomes
por: Young-Baird, Sara K.
Publicado: (2022)

A blueprint for academic laboratories to produce SARS-CoV-2 quantitative RT-PCR test kits
por: Mascuch, Samantha J., et al.
Publicado: (2020)

The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor
por: Todd, Brendan, et al.
Publicado: (2021)

The intracellular immune receptor Rx1 regulates the DNA-binding activity of a Golden2-like transcription factor
por: Townsend, Philip D., et al.
Publicado: (2018)

ARL11 regulates lipopolysaccharide-stimulated macrophage activation by promoting mitogen-activated protein kinase (MAPK) signaling
por: Arya, Subhash B., et al.
Publicado: (2018)

Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells
por: Wan, Qingwen, et al.
Publicado: (2018)

Discovery of peptide ligands targeting a specific ubiquitin-like domain–binding site in the deubiquitinase USP11
por: Spiliotopoulos, Anastasios, et al.
Publicado: (2019)

Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multiparametric imaging
por: Lu, Meng, et al.
Publicado: (2019)

A low-potential terminal oxidase associated with the iron-only nitrogenase from the nitrogen-fixing bacterium Azotobacter vinelandii
por: Varghese, Febin, et al.
Publicado: (2019)

The NifZ accessory protein has an equivalent function in maturation of both nitrogenase MoFe protein P-clusters
por: Jimenez-Vicente, Emilio, et al.
Publicado: (2019)

Liquid–liquid phase separation of tau protein: The crucial role of electrostatic interactions
por: Boyko, Solomiia, et al.
Publicado: (2019)

Structure–function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-κB
por: Jennings, Elliott, et al.
Publicado: (2018)

Autophosphorylation-based Calcium (Ca(2+)) Sensitivity Priming and Ca(2+)/Calmodulin Inhibition of Arabidopsis thaliana Ca(2+)-dependent Protein Kinase 28 (CPK28)
por: Bender, Kyle W., et al.
Publicado: (2017)

Yersinia effector protein (YopO)-mediated phosphorylation of host gelsolin causes calcium-independent activation leading to disruption of actin dynamics
por: Singaravelu, Pavithra, et al.
Publicado: (2017)

An amphipathic α-helix directs palmitoylation of the large intracellular loop of the sodium/calcium exchanger
por: Plain, Fiona, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gd1ejcond188b64e76riul8vo7