Cargando…

Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment

New tools are needed to match cancer patients with effective treatments. Patient-derived organoids offer a high-throughput platform to personalize treatments and discover novel therapies. Currently, methods to evaluate drug response in organoids are limited because they overlook cellular heterogenei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sharick, Joe T., Walsh, Christine M., Sprackling, Carley M., Pasch, Cheri A., Pham, Dan L., Esbona, Karla, Choudhary, Alka, Garcia-Valera, Rebeca, Burkard, Mark E., McGregor, Stephanie M., Matkowskyj, Kristina A., Parikh, Alexander A., Meszoely, Ingrid M., Kelley, Mark C., Tsai, Susan, Deming, Dustin A., Skala, Melissa C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242740/ https://www.ncbi.nlm.nih.gov/pubmed/32500020 http://dx.doi.org/10.3389/fonc.2020.00553

Ejemplares similares

Autofluorescence Imaging of Treatment Response in Neuroendocrine Tumor Organoids
por: Gillette, Amani A., et al.
Publicado: (2021)

Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids()
por: Sharick, Joe T., et al.
Publicado: (2019)

Impact of baseline culture conditions of cancer organoids when determining therapeutic response and tumor heterogeneity
por: DeStefanis, Rebecca A., et al.
Publicado: (2022)

Patient-derived cancer organoid tracking with wide-field one-photon redox imaging to assess treatment response
por: Gil, Daniel A., et al.
Publicado: (2021)

Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K
por: Yueh, Alexander E., et al.
Publicado: (2016)

Live cell molecular analysis of primary prostate cancer organoids identifies persistent androgen receptor signaling
por: Heninger, Erika, et al.
Publicado: (2021)

Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications
por: Datta, Rupsa, et al.
Publicado: (2020)

Liquids and solids
por: Sprackling, M T
Publicado: (1985)

Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment
por: Papadas, Athanasios, et al.
Publicado: (2022)

Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer
por: Singh, Ashok, et al.
Publicado: (2020)

Metabolic Imaging of Head and Neck Cancer Organoids
por: Shah, Amy T., et al.
Publicado: (2017)

Protein-bound NAD(P)H Lifetime is Sensitive to Multiple Fates of Glucose Carbon
por: Sharick, Joe T., et al.
Publicado: (2018)

Redox imaging and optical coherence tomography of the respiratory ciliated epithelium
por: Gil, Daniel A., et al.
Publicado: (2019)

PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors
por: Payne, S N, et al.
Publicado: (2015)

Inhibition of B-cell lymphoma 2 family proteins alters optical redox ratio, mitochondrial polarization, and cell energetics independent of cell state
por: Gillette, Amani A., et al.
Publicado: (2022)

Genetically engineered cerebral organoids model brain tumour formation
por: Bian, Shan, et al.
Publicado: (2018)

Mad1 destabilizes p53 by preventing PML from sequestering MDM2
por: Wan, Jun, et al.
Publicado: (2019)

Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer
por: Tucker, John B., et al.
Publicado: (2023)

Analysis of Synapses in Cerebral Organoids
por: Yakoub, Abraam M., et al.
Publicado: (2019)

Evaluation of biological agents targeted at early-stage disease
por: Guix, Marta, et al.
Publicado: (2008)

Titin Diversity—Alternative Splicing Gone Wild
por: Guo, Wei, et al.
Publicado: (2010)

Drug response in organoids generated from frozen primary tumor tissues
por: Walsh, Alex J., et al.
Publicado: (2016)

Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response
por: Walsh, Alex J., et al.
Publicado: (2016)

Author Correction: Drug response in organoids generated from frozen primary tumor tissues
por: Walsh, Alex J., et al.
Publicado: (2019)

Vascularized Tissue Organoids
por: Strobel, Hannah A., et al.
Publicado: (2023)

Development and Characterization of Human Cerebral Organoids: An Optimized Protocol
por: Yakoub, Abraam M., et al.
Publicado: (2018)

Phospholipid Ether Analogs for the Detection of Colorectal Tumors
por: Deming, Dustin A., et al.
Publicado: (2014)

Opportunities for organoids as new models of aging
por: Hu, Jennifer L., et al.
Publicado: (2018)

Evaluating feasibility of an automated 3-dimensional scanner using Raman spectroscopy for intraoperative breast margin assessment
por: Thomas, G., et al.
Publicado: (2017)

COX-2 modulates mammary tumor progression in response to collagen density
por: Esbona, Karla, et al.
Publicado: (2016)

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta
por: Haider, Sandra, et al.
Publicado: (2018)

A simple and efficient method for generating human retinal organoids
por: Regent, Florian, et al.
Publicado: (2020)

Advances in immunotherapeutic strategies for colorectal cancer commentary on: tumoral immune cell exploitation in colorectal cancer metastases can be targeted effectively by anti-CCR5 therapy in cancer patients by Halama et al
por: Deming, Dustin A.
Publicado: (2016)

Human organoids are superior to cell culture models for intestinal barrier research
por: Kollmann, Catherine, et al.
Publicado: (2023)

Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid
por: Branco, Mariana A., et al.
Publicado: (2022)

Flow-enhanced vascularization and maturation of kidney organoids in vitro
por: Homan, Kimberly A., et al.
Publicado: (2019)

Single-cell brain organoid screening identifies developmental defects in autism
por: Li, Chong, et al.
Publicado: (2023)

A simplified protocol for the generation of cortical brain organoids
por: Eigenhuis, Kristel N., et al.
Publicado: (2023)

Towards organoid culture without Matrigel
por: Kozlowski, Mark T., et al.
Publicado: (2021)

Derivation of adult canine intestinal organoids for translational research in gastroenterology
por: Chandra, Lawrance, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4ue4lu6vnhnc104gl4o0l4vlro