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Sildenafil for the Treatment of Alzheimer’s Disease: A Systematic Review

Nitric oxide/cyclic guanosine monophosphate (cGMP) signaling is compromised in Alzheimer’s disease (AD), and phosphodiesterase 5 (PDE5), which degrades cGMP, is upregulated. Sildenafil inhibits PDE5 and increases cGMP levels. Integrating previous findings, we determine that most doses of sildenafil...

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Detalles Bibliográficos
Autor principal:	Sanders, Owen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242821/ https://www.ncbi.nlm.nih.gov/pubmed/32467879 http://dx.doi.org/10.3233/ADR-200166

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