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In-clinic event related potentials after sports concussion: A 4-year study

PURPOSE: Electrophysiological event-related potentials (ERP’s) have been reported to change after concussion. The objective of this study is to use a simple 2-tone auditory P300 ERP in routine clinical settings to measure changes from baseline after concussion and to determine if these changes persi...

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Autores principales: Clayton, Gerald, Davis, Natalie, Holliday, Adam, Joffe, David, Oakley, David S., Palermo, Francis X., Poddar, Sourav, Rueda, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242851/
https://www.ncbi.nlm.nih.gov/pubmed/32176669
http://dx.doi.org/10.3233/PRM-190620
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author Clayton, Gerald
Davis, Natalie
Holliday, Adam
Joffe, David
Oakley, David S.
Palermo, Francis X.
Poddar, Sourav
Rueda, Miguel
author_facet Clayton, Gerald
Davis, Natalie
Holliday, Adam
Joffe, David
Oakley, David S.
Palermo, Francis X.
Poddar, Sourav
Rueda, Miguel
author_sort Clayton, Gerald
collection PubMed
description PURPOSE: Electrophysiological event-related potentials (ERP’s) have been reported to change after concussion. The objective of this study is to use a simple 2-tone auditory P300 ERP in routine clinical settings to measure changes from baseline after concussion and to determine if these changes persist at return to play when other standard measures have normalized. METHODS: Three-hundred sixty-four (364) student athletes, aged 17–23 years, participating in contact sports were tracked over consecutive years. In this blinded study P300, plus physical reaction times and Trail Making tests, were collected alongside standard clinical evaluations. Changes in these measures after concussion were compared to clinical outcomes over various stages of post-injury recovery. RESULTS: Concussed players experienced significant reaction time and/or P300 amplitude changes compared to pre-concussion baseline measurements ([Formula: see text] 0.005). P300 changes persisted in 38% of the players after standard measures, including reaction times, had cleared. Many of those players slow to normalize were part of the sub-concussive symptom group and/or appeared more prone to repeat concussions. CONCLUSION: These data suggest significant P300 amplitude changes after concussion that are quantifiable and consistent. These changes often normalized slower than other standard assessments. More data are needed to determine if slow normalization relates to sub-concussive or repeated events.
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spelling pubmed-72428512020-05-27 In-clinic event related potentials after sports concussion: A 4-year study Clayton, Gerald Davis, Natalie Holliday, Adam Joffe, David Oakley, David S. Palermo, Francis X. Poddar, Sourav Rueda, Miguel J Pediatr Rehabil Med Research Article PURPOSE: Electrophysiological event-related potentials (ERP’s) have been reported to change after concussion. The objective of this study is to use a simple 2-tone auditory P300 ERP in routine clinical settings to measure changes from baseline after concussion and to determine if these changes persist at return to play when other standard measures have normalized. METHODS: Three-hundred sixty-four (364) student athletes, aged 17–23 years, participating in contact sports were tracked over consecutive years. In this blinded study P300, plus physical reaction times and Trail Making tests, were collected alongside standard clinical evaluations. Changes in these measures after concussion were compared to clinical outcomes over various stages of post-injury recovery. RESULTS: Concussed players experienced significant reaction time and/or P300 amplitude changes compared to pre-concussion baseline measurements ([Formula: see text] 0.005). P300 changes persisted in 38% of the players after standard measures, including reaction times, had cleared. Many of those players slow to normalize were part of the sub-concussive symptom group and/or appeared more prone to repeat concussions. CONCLUSION: These data suggest significant P300 amplitude changes after concussion that are quantifiable and consistent. These changes often normalized slower than other standard assessments. More data are needed to determine if slow normalization relates to sub-concussive or repeated events. IOS Press 2020-04-13 /pmc/articles/PMC7242851/ /pubmed/32176669 http://dx.doi.org/10.3233/PRM-190620 Text en © 2020 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).
spellingShingle Research Article
Clayton, Gerald
Davis, Natalie
Holliday, Adam
Joffe, David
Oakley, David S.
Palermo, Francis X.
Poddar, Sourav
Rueda, Miguel
In-clinic event related potentials after sports concussion: A 4-year study
title In-clinic event related potentials after sports concussion: A 4-year study
title_full In-clinic event related potentials after sports concussion: A 4-year study
title_fullStr In-clinic event related potentials after sports concussion: A 4-year study
title_full_unstemmed In-clinic event related potentials after sports concussion: A 4-year study
title_short In-clinic event related potentials after sports concussion: A 4-year study
title_sort in-clinic event related potentials after sports concussion: a 4-year study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242851/
https://www.ncbi.nlm.nih.gov/pubmed/32176669
http://dx.doi.org/10.3233/PRM-190620
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