Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease

OBJECTIVE: Discoidin domain receptor 1 (DDR1) is a collagen binding receptor tyrosine kinase implicated in atherosclerosis, fibrosis, and cancer. Our previous research showed that DDR1 could regulate smooth muscle cell trans-differentiation, fibrosis and calcification in the vascular system in cardi...

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Detalles Bibliográficos
Autores principales: Lino, Marsel, Ngai, David, Liu, Alison, Mohabeer, Amanda, Harper, Cameron, Caruso, Laura-lee, Schroer, Stephanie A., Fu, Fred, McKee, Trevor, Giacca, Adria, Woo, Minna, Bendeck, Michelle P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242876/
https://www.ncbi.nlm.nih.gov/pubmed/32360427
http://dx.doi.org/10.1016/j.molmet.2020.101006

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