Sodium–glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice

Inhibition of sodium–glucose cotransporter 2 (SGLT2) in the proximal tubule of the kidney has emerged as an effective antihyperglycemic treatment. The potential protective role of SGLT2 inhibition on diabetic kidney disease (DKD) and underlying mechanism, however, remains unknown. In this study, met...

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Detalles Bibliográficos
Autores principales: Cai, Ting, Ke, Qingqing, Fang, Yi, Wen, Ping, Chen, Hanzhi, Yuan, Qi, Luo, Jing, Zhang, Yu, Sun, Qi, Lv, Yunhui, Zen, Ke, Jiang, Lei, Zhou, Yang, Yang, Junwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242894/
https://www.ncbi.nlm.nih.gov/pubmed/32444604
http://dx.doi.org/10.1038/s41419-020-2544-7

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