Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes an...

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Detalles Bibliográficos
Autores principales: Kitchen, Philip, Salman, Mootaz M., Halsey, Andrea M., Clarke-Bland, Charlotte, MacDonald, Justin A., Ishida, Hiroaki, Vogel, Hans J., Almutiri, Sharif, Logan, Ann, Kreida, Stefan, Al-Jubair, Tamim, Winkel Missel, Julie, Gourdon, Pontus, Törnroth-Horsefield, Susanna, Conner, Matthew T., Ahmed, Zubair, Conner, Alex C., Bill, Roslyn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242911/
https://www.ncbi.nlm.nih.gov/pubmed/32413299
http://dx.doi.org/10.1016/j.cell.2020.03.037

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