COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor

COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the path...

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Detalles Bibliográficos
Autores principales: Mjaess, G., Karam, A., Aoun, F., Albisinni, S., Roumeguère, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242948/
https://www.ncbi.nlm.nih.gov/pubmed/32620366
http://dx.doi.org/10.1016/j.purol.2020.05.007
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author Mjaess, G.
Karam, A.
Aoun, F.
Albisinni, S.
Roumeguère, T.
author_facet Mjaess, G.
Karam, A.
Aoun, F.
Albisinni, S.
Roumeguère, T.
author_sort Mjaess, G.
collection PubMed
description COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the pathophysiology of this sex-discrepancy, based on the infectivity mechanism of the coronavirus including the Angiotensin-Converting Enzyme 2 (ACE2), the Type II transmembrane Serine Protease (TMPRSS2), and the androgen receptor. This could help understand the susceptibility of urological patients, especially those receiving androgen deprivation therapy for prostate cancer, and testosterone replacement therapy.
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spelling pubmed-72429482020-05-22 COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor Mjaess, G. Karam, A. Aoun, F. Albisinni, S. Roumeguère, T. Prog Urol Short Communication COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the pathophysiology of this sex-discrepancy, based on the infectivity mechanism of the coronavirus including the Angiotensin-Converting Enzyme 2 (ACE2), the Type II transmembrane Serine Protease (TMPRSS2), and the androgen receptor. This could help understand the susceptibility of urological patients, especially those receiving androgen deprivation therapy for prostate cancer, and testosterone replacement therapy. Elsevier Masson SAS. 2020-09 2020-05-22 /pmc/articles/PMC7242948/ /pubmed/32620366 http://dx.doi.org/10.1016/j.purol.2020.05.007 Text en © 2020 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Mjaess, G.
Karam, A.
Aoun, F.
Albisinni, S.
Roumeguère, T.
COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor
title COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor
title_full COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor
title_fullStr COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor
title_full_unstemmed COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor
title_short COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor
title_sort covid-19 and the male susceptibility: the role of ace2, tmprss2 and the androgen receptor
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242948/
https://www.ncbi.nlm.nih.gov/pubmed/32620366
http://dx.doi.org/10.1016/j.purol.2020.05.007
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