TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis

Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid prog...

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Detalles Bibliográficos
Autores principales: Chen, Xue-Yan, Yan, Bing-Xi, Man, Xiao-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243041/
https://www.ncbi.nlm.nih.gov/pubmed/32436460
http://dx.doi.org/10.1177/1753466620926800
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author Chen, Xue-Yan
Yan, Bing-Xi
Man, Xiao-Yong
author_facet Chen, Xue-Yan
Yan, Bing-Xi
Man, Xiao-Yong
author_sort Chen, Xue-Yan
collection PubMed
description Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFα, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. The reviews of this paper are available via the supplemental material section.
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spelling pubmed-72430412020-05-22 TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis Chen, Xue-Yan Yan, Bing-Xi Man, Xiao-Yong Ther Adv Respir Dis Review Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFα, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. The reviews of this paper are available via the supplemental material section. SAGE Publications 2020-05-21 /pmc/articles/PMC7243041/ /pubmed/32436460 http://dx.doi.org/10.1177/1753466620926800 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Chen, Xue-Yan
Yan, Bing-Xi
Man, Xiao-Yong
TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
title TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
title_full TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
title_fullStr TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
title_full_unstemmed TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
title_short TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
title_sort tnfα inhibitor may be effective for severe covid-19: learning from toxic epidermal necrolysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243041/
https://www.ncbi.nlm.nih.gov/pubmed/32436460
http://dx.doi.org/10.1177/1753466620926800
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