Cargando…
Andersen–Tawil Syndrome Is Associated With Impaired PIP(2) Regulation of the Potassium Channel Kir2.1
Andersen–Tawil syndrome (ATS) type-1 is associated with loss-of-function mutations in KCNJ2 gene. KCNJ2 encodes the tetrameric inward-rectifier potassium channel Kir2.1, important to the resting phase of the cardiac action potential. Kir-channels’ activity requires interaction with the agonist phosp...
Autores principales: | Handklo-Jamal, Reem, Meisel, Eshcar, Yakubovich, Daniel, Vysochek, Leonid, Beinart, Roy, Glikson, Michael, McMullen, Julie R., Dascal, Nathan, Nof, Eyal, Oz, Shimrit |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243181/ https://www.ncbi.nlm.nih.gov/pubmed/32499698 http://dx.doi.org/10.3389/fphar.2020.00672 |
Ejemplares similares
-
Mutations in Na(V)1.5 Reveal Calcium-Calmodulin Regulation of Sodium Channel
por: Nof, Eyal, et al.
Publicado: (2019) -
Andersen-Tawil Syndrome
por: Smith, Andrew H, et al.
Publicado: (2006) -
Electrocardiogram in Andersen-Tawil Syndrome. New Electrocardiographic Criteria for Diagnosis of Type-1 Andersen-Tawil Syndrome
por: Kukla, Piotr, et al.
Publicado: (2014) -
Extracellular cysteine disulfide bond break at Cys122 disrupts PIP(2)-dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome
por: Cruz, Francisco M., et al.
Publicado: (2023) -
Ventricular Tachyarrhythmias in a Patient with Andersen-Tawil Syndrome
por: Pyo, Jung Yoon, et al.
Publicado: (2013)