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Repurposing Doxepin to Ameliorate Steatosis and Hyperglycemia by Activating FAM3A Signaling Pathway

Mitochondrial protein FAM3A suppresses hepatic gluconeogenesis and lipogenesis. This study aimed to screen drug(s) that activates FAM3A expression and evaluate its effect(s) on hyperglycemia and steatosis. Drug-repurposing methodology predicted that antidepressive drug doxepin was among the drugs th...

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Detalles Bibliográficos
Autores principales:	Chen, Zhenzhen, Liu, Xiangyang, Luo, Yanjin, Wang, Junpei, Meng, Yuhong, Sun, Lei, Chang, Yongsheng, Cui, Qinghua, Yang, Jichun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2020
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243289/ https://www.ncbi.nlm.nih.gov/pubmed/32312868 http://dx.doi.org/10.2337/db19-1038

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