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Evaluation of Clinically Meaningful Changes in Measures of Frailty

BACKGROUND: To determine the clinically meaningful changes and responsiveness of widely used frailty measures. METHODS: We analyzed data from a prospective cohort study of 1,135 community-dwelling older adults who underwent assessments of frailty and health-related quality of life using the EuroQol-...

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Autores principales: Jang, Il-Young, Jung, Hee-Won, Lee, Hea Yon, Park, Hyungchul, Lee, Eunju, Kim, Dae Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243580/
https://www.ncbi.nlm.nih.gov/pubmed/32145016
http://dx.doi.org/10.1093/gerona/glaa003
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author Jang, Il-Young
Jung, Hee-Won
Lee, Hea Yon
Park, Hyungchul
Lee, Eunju
Kim, Dae Hyun
author_facet Jang, Il-Young
Jung, Hee-Won
Lee, Hea Yon
Park, Hyungchul
Lee, Eunju
Kim, Dae Hyun
author_sort Jang, Il-Young
collection PubMed
description BACKGROUND: To determine the clinically meaningful changes and responsiveness of widely used frailty measures. METHODS: We analyzed data from a prospective cohort study of 1,135 community-dwelling older adults who underwent assessments of frailty and health-related quality of life using the EuroQol-5D at baseline and 1 year later. Frailty measures included deficit-accumulation frailty index (FI); frailty phenotype; Fatigue, Resistance, Ambulation, Illness, and Loss of Weight scale; and the Study of Osteoporotic Fracture (SOF) index. We determined the clinically meaningful changes by the distribution-based method and the anchor-based method using the EuroQol-5D score and responsiveness indices. RESULTS: Frailty measures were available in 925 participants at 1 year (81.5%). Based on the distribution-based method, small and large clinically meaningful changes were 0.019 and 0.057 for FI, 0.249 and 0.623 for frailty phenotype, 0.235 and 0.587 for FRAIL scale, and 0.116 and 0.289 for SOF index, respectively. The anchor-based estimates of small and large changes were 0.028 and 0.076 for FI, 0.097 and 0.607 for frailty phenotype, 0.269 and 0.368 for FRAIL scale, and 0.023 and 0.287 for SOF index, respectively. Based on the responsiveness index, per-group sample sizes to achieve 80% power in clinical trials, ranged from 51 (FI) to 7,272 (SOF index) for a small change and 9 (FI) to 133 (FRAIL scale) for a large change. CONCLUSIONS: The estimates of clinically meaningful change of frailty measures can inform the choice of frailty measures to track longitudinal changes of frailty in clinical trials and clinical care of community-dwelling older adults.
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spelling pubmed-72435802020-05-27 Evaluation of Clinically Meaningful Changes in Measures of Frailty Jang, Il-Young Jung, Hee-Won Lee, Hea Yon Park, Hyungchul Lee, Eunju Kim, Dae Hyun J Gerontol A Biol Sci Med Sci THE JOURNAL OF GERONTOLOGY: Medical Sciences BACKGROUND: To determine the clinically meaningful changes and responsiveness of widely used frailty measures. METHODS: We analyzed data from a prospective cohort study of 1,135 community-dwelling older adults who underwent assessments of frailty and health-related quality of life using the EuroQol-5D at baseline and 1 year later. Frailty measures included deficit-accumulation frailty index (FI); frailty phenotype; Fatigue, Resistance, Ambulation, Illness, and Loss of Weight scale; and the Study of Osteoporotic Fracture (SOF) index. We determined the clinically meaningful changes by the distribution-based method and the anchor-based method using the EuroQol-5D score and responsiveness indices. RESULTS: Frailty measures were available in 925 participants at 1 year (81.5%). Based on the distribution-based method, small and large clinically meaningful changes were 0.019 and 0.057 for FI, 0.249 and 0.623 for frailty phenotype, 0.235 and 0.587 for FRAIL scale, and 0.116 and 0.289 for SOF index, respectively. The anchor-based estimates of small and large changes were 0.028 and 0.076 for FI, 0.097 and 0.607 for frailty phenotype, 0.269 and 0.368 for FRAIL scale, and 0.023 and 0.287 for SOF index, respectively. Based on the responsiveness index, per-group sample sizes to achieve 80% power in clinical trials, ranged from 51 (FI) to 7,272 (SOF index) for a small change and 9 (FI) to 133 (FRAIL scale) for a large change. CONCLUSIONS: The estimates of clinically meaningful change of frailty measures can inform the choice of frailty measures to track longitudinal changes of frailty in clinical trials and clinical care of community-dwelling older adults. Oxford University Press 2020-05 2020-03-07 /pmc/articles/PMC7243580/ /pubmed/32145016 http://dx.doi.org/10.1093/gerona/glaa003 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle THE JOURNAL OF GERONTOLOGY: Medical Sciences
Jang, Il-Young
Jung, Hee-Won
Lee, Hea Yon
Park, Hyungchul
Lee, Eunju
Kim, Dae Hyun
Evaluation of Clinically Meaningful Changes in Measures of Frailty
title Evaluation of Clinically Meaningful Changes in Measures of Frailty
title_full Evaluation of Clinically Meaningful Changes in Measures of Frailty
title_fullStr Evaluation of Clinically Meaningful Changes in Measures of Frailty
title_full_unstemmed Evaluation of Clinically Meaningful Changes in Measures of Frailty
title_short Evaluation of Clinically Meaningful Changes in Measures of Frailty
title_sort evaluation of clinically meaningful changes in measures of frailty
topic THE JOURNAL OF GERONTOLOGY: Medical Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243580/
https://www.ncbi.nlm.nih.gov/pubmed/32145016
http://dx.doi.org/10.1093/gerona/glaa003
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