Cargando…

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells

Hutchinson-Gilford progeria syndrome (HGPS, or classical progeria) is a rare genetic disorder, characterized by premature aging, and caused by a de novo point mutation (C608G) within the lamin A/C gene (LMNA), producing an abnormal lamin A protein, termed progerin. Accumulation of progerin causes nu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aveleira, Célia A, Ferreira-Marques, Marisa, Cortes, Luísa, Valero, Jorge, Pereira, Dina, Pereira de Almeida, Luís, Cavadas, Cláudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	THE JOURNAL OF GERONTOLOGY: Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243588/ https://www.ncbi.nlm.nih.gov/pubmed/32012215 http://dx.doi.org/10.1093/gerona/glz280

Ejemplares similares

Sulforaphane enhances progerin clearance in Hutchinson–Gilford progeria fibroblasts
por: Gabriel, Diana, et al.
Publicado: (2015)

Efficient progerin clearance through autophagy induction and SRSF-1 downregulation in Hutchinson-Gilford Progeria Syndrome
por: Harhouri, Karim
Publicado: (2015)

Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria
por: Chojnowski, Alexandre, et al.
Publicado: (2015)

Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry
por: Camafeita, Emilio, et al.
Publicado: (2022)

Heterochromatin loss as a determinant of progerin‐induced DNA damage in Hutchinson–Gilford Progeria
por: Chojnowski, Alexandre, et al.
Publicado: (2020)

Impact of Progerin Expression on Adipogenesis in Hutchinson—Gilford Progeria Skin-Derived Precursor Cells
por: Najdi, Farah, et al.
Publicado: (2021)

Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome
por: Sánchez-López, Amanda, et al.
Publicado: (2021)

Plasma Progerin in Patients With Hutchinson-Gilford Progeria Syndrome: Immunoassay Development and Clinical Evaluation
por: Gordon, Leslie B., et al.
Publicado: (2023)

Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
por: Kang, So-mi, et al.
Publicado: (2021)

Hutchinson-Gilford progeria syndrome
por: Bhukya, Amar Singh, et al.
Publicado: (2015)

Activating the synthesis of progerin, the mutant prelamin A in Hutchinson–Gilford progeria syndrome, with antisense oligonucleotides
por: Fong, Loren G., et al.
Publicado: (2009)

Metformin decreases progerin expression and alleviates pathological defects of Hutchinson–Gilford progeria syndrome cells
por: Egesipe, Anne-Laure, et al.
Publicado: (2016)

Progerinin, an Inhibitor of Progerin, Alleviates Cardiac Abnormalities in a Model Mouse of Hutchinson–Gilford Progeria Syndrome
por: Kang, So-mi, et al.
Publicado: (2023)

Author Correction: Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
por: Kang, So-mi, et al.
Publicado: (2021)

Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts
por: Eisch, Veronika, et al.
Publicado: (2016)

Unique progerin C-terminal peptide ameliorates Hutchinson–Gilford progeria syndrome phenotype by rescuing BUBR1
por: Zhang, Na, et al.
Publicado: (2023)

Ocular manifestations in the Hutchinson-Gilford progeria syndrome
por: Chandravanshi, Shivcharan L, et al.
Publicado: (2011)

Hutchinson-Gilford Progeria Versus Mandibuloacral Dysplasia
por: Mehrez, Mennat Allah I, et al.
Publicado: (2014)

microRNA deregulation in Hutchinson-Gilford Progeria
por: Roll, Patrice
Publicado: (2015)

Metabolic Dysfunction in Hutchinson–Gilford Progeria Syndrome
por: Kreienkamp, Ray, et al.
Publicado: (2020)

Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo
por: Wenzel, Vera, et al.
Publicado: (2012)

Progerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation
por: Noda, Asao, et al.
Publicado: (2015)

Erythrocyte Senescence in a Model of Rat Displaying Hutchinson-Gilford Progeria Syndrome
por: Chaudhary, Manoj Kumar, et al.
Publicado: (2018)

Vascular Smooth Muscle–Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome
por: Hamczyk, Magda R., et al.
Publicado: (2018)

Author Correction: Unique progerin C-terminal peptide ameliorates Hutchinson–Gilford progeria syndrome phenotype by rescuing BUBR1
por: Zhang, Na, et al.
Publicado: (2023)

An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome
por: Harhouri, Karim, et al.
Publicado: (2018)

Hutchinson–Gilford Progeria Syndrome: Clinical and Molecular Characterization
por: Pachajoa, Harry, et al.
Publicado: (2020)

Hutchinson-Gilford Progeria Syndrome: A Literature Review
por: Lamis, Aselah, et al.
Publicado: (2022)

Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome
por: Díez-Díez, Miriam, et al.
Publicado: (2022)

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
por: Columbaro, M., et al.
Publicado: (2005)

Hutchinson-Gilford Progeria Syndrome: A Rare Genetic Disorder
por: Panigrahi, Rajat G., et al.
Publicado: (2013)

Hutchinson – Gilford progeria syndrome: A rare case report
por: Kashyap, Subhash, et al.
Publicado: (2014)

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype
por: Gabriel, Diana, et al.
Publicado: (2016)

Progress and trends in the development of therapies for Hutchinson–Gilford progeria syndrome
por: Lai, Wing‐Fu, et al.
Publicado: (2020)

Peroxisomal abnormalities and catalase deficiency in Hutchinson-Gilford Progeria Syndrome
por: Mao, Xiaojing, et al.
Publicado: (2020)

Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria Syndrome
por: Marcos-Ramiro, Beatriz, et al.
Publicado: (2021)

Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome
por: Mu, Xiaodong, et al.
Publicado: (2020)

A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells
por: Chen, Xue, et al.
Publicado: (2021)

Progerin mislocalizes myocardin-related transcription factor in Hutchinson–Guilford Progeria syndrome
por: von Kleeck, Ryan, et al.
Publicado: (2022)

Hutchinson–Gilford progeria syndrome with severe calcific aortic valve stenosis
por: Hanumanthappa, Natesh B, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_add53l36hl8qat92njg9uj8v09