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The Relationship between Chemokine Ligand 3 and Allergic Rhinitis

Background Allergic rhinitis (AR) is a chronic and frequent condition characterized by an excessive response of the immune system to innocent substances encountered in the nasal mucosa. These reactions are mediated by many factors, including chemokines. Chemokine ligand 3 (CCL3, a macrophage inflamm...

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Autores principales: Berghi, Ovidiu, Dumitru, Mihai, Caragheorgheopol, Ramona, Tucureanu, Catalin, Simioniuc-Petrescu, Anca, Sfrent-Cornateanu, Roxana, Giurcaneanu, Calin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243633/
https://www.ncbi.nlm.nih.gov/pubmed/32461855
http://dx.doi.org/10.7759/cureus.7783
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author Berghi, Ovidiu
Dumitru, Mihai
Caragheorgheopol, Ramona
Tucureanu, Catalin
Simioniuc-Petrescu, Anca
Sfrent-Cornateanu, Roxana
Giurcaneanu, Calin
author_facet Berghi, Ovidiu
Dumitru, Mihai
Caragheorgheopol, Ramona
Tucureanu, Catalin
Simioniuc-Petrescu, Anca
Sfrent-Cornateanu, Roxana
Giurcaneanu, Calin
author_sort Berghi, Ovidiu
collection PubMed
description Background Allergic rhinitis (AR) is a chronic and frequent condition characterized by an excessive response of the immune system to innocent substances encountered in the nasal mucosa. These reactions are mediated by many factors, including chemokines. Chemokine ligand 3 (CCL3, a macrophage inflammatory protein 1α) is a chemokine implicated in the activation of mast cells - white cells shown to be highly involved in orchestrating allergic reactions. The present study evaluated the role of CCL3 in AR. Material and methods Thirty-nine participants, including 24 patients with AR and 15 healthy controls, were evaluated for allergies to dust mites, cat and dog danders, cockroaches (Blatella germanica), molds, grasses, weeds, and tree pollen using skin prick tests. Participants were also evaluated for inflammatory conditions by measuring total blood count with differential; concentrations of rheumatoid factor, fibrinogen, and C-reactive protein; and erythrocyte sedimentation rate. CCL3 in blood samples was measured at the Immunology Laboratory, Cantacuzino National Institute for Military Medical Research and Development, Bucharest, Romania, using Human Multianalyte Profiling Base Kits (R&D Systems Inc., Minneapolis, MN). Results Mean serum CCL3 concentration was significantly higher in patients with AR than in controls (15.03 ± 7.11 pg/ml vs. 8.34 ± 4.46 pg/ml, p = 0.001 [t-test] and p = 0.026 [Mann-Whitney test]). CCL3 concentrations correlated with polysensitization, defined as two or more positive prick tests per patient (r = 0.325, p = 0.046) and seasonal AR (r = 0.482, p = 0.002). Conclusions Elevated levels of CCL3 were seen in our patients with AR. We have observed correlations with polysensitization and seasonal allergies. These results suggest that chemokines might play an important role in the pathogenesis of AR. In the future, chemokines might be used in endotype classification of patients with AR and as a possible target in the treatment of AR.
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spelling pubmed-72436332020-05-26 The Relationship between Chemokine Ligand 3 and Allergic Rhinitis Berghi, Ovidiu Dumitru, Mihai Caragheorgheopol, Ramona Tucureanu, Catalin Simioniuc-Petrescu, Anca Sfrent-Cornateanu, Roxana Giurcaneanu, Calin Cureus Otolaryngology Background Allergic rhinitis (AR) is a chronic and frequent condition characterized by an excessive response of the immune system to innocent substances encountered in the nasal mucosa. These reactions are mediated by many factors, including chemokines. Chemokine ligand 3 (CCL3, a macrophage inflammatory protein 1α) is a chemokine implicated in the activation of mast cells - white cells shown to be highly involved in orchestrating allergic reactions. The present study evaluated the role of CCL3 in AR. Material and methods Thirty-nine participants, including 24 patients with AR and 15 healthy controls, were evaluated for allergies to dust mites, cat and dog danders, cockroaches (Blatella germanica), molds, grasses, weeds, and tree pollen using skin prick tests. Participants were also evaluated for inflammatory conditions by measuring total blood count with differential; concentrations of rheumatoid factor, fibrinogen, and C-reactive protein; and erythrocyte sedimentation rate. CCL3 in blood samples was measured at the Immunology Laboratory, Cantacuzino National Institute for Military Medical Research and Development, Bucharest, Romania, using Human Multianalyte Profiling Base Kits (R&D Systems Inc., Minneapolis, MN). Results Mean serum CCL3 concentration was significantly higher in patients with AR than in controls (15.03 ± 7.11 pg/ml vs. 8.34 ± 4.46 pg/ml, p = 0.001 [t-test] and p = 0.026 [Mann-Whitney test]). CCL3 concentrations correlated with polysensitization, defined as two or more positive prick tests per patient (r = 0.325, p = 0.046) and seasonal AR (r = 0.482, p = 0.002). Conclusions Elevated levels of CCL3 were seen in our patients with AR. We have observed correlations with polysensitization and seasonal allergies. These results suggest that chemokines might play an important role in the pathogenesis of AR. In the future, chemokines might be used in endotype classification of patients with AR and as a possible target in the treatment of AR. Cureus 2020-04-22 /pmc/articles/PMC7243633/ /pubmed/32461855 http://dx.doi.org/10.7759/cureus.7783 Text en Copyright © 2020, Berghi et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Otolaryngology
Berghi, Ovidiu
Dumitru, Mihai
Caragheorgheopol, Ramona
Tucureanu, Catalin
Simioniuc-Petrescu, Anca
Sfrent-Cornateanu, Roxana
Giurcaneanu, Calin
The Relationship between Chemokine Ligand 3 and Allergic Rhinitis
title The Relationship between Chemokine Ligand 3 and Allergic Rhinitis
title_full The Relationship between Chemokine Ligand 3 and Allergic Rhinitis
title_fullStr The Relationship between Chemokine Ligand 3 and Allergic Rhinitis
title_full_unstemmed The Relationship between Chemokine Ligand 3 and Allergic Rhinitis
title_short The Relationship between Chemokine Ligand 3 and Allergic Rhinitis
title_sort relationship between chemokine ligand 3 and allergic rhinitis
topic Otolaryngology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243633/
https://www.ncbi.nlm.nih.gov/pubmed/32461855
http://dx.doi.org/10.7759/cureus.7783
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